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Merck
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文件

P1101

Sigma-Aldrich

D-青霉胺二硫化物

97%, cell analysis

别名:

3,3′-二硫代双(2-氨基-3-甲基丁酸), S,S′-二(D-青霉胺), 二硫青霉胺

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About This Item

线性分子式:
[-SC(CH3)2CH(NH2)CO2H]2
CAS号:
20902-45-8
分子量:
296.41
Beilstein:
4461521
EC號碼:
244-107-2
MDL號碼:
MFCD00004264
分類程式碼代碼:
12352116
PubChem物質ID:
24898153
NACRES:
NA.22

product name

D-青霉胺二硫化物, 97%

化驗

97%

形狀

powder or crystals

光學活性

[α]25/D −75°, c = 1 in 1 M NaOH

反應適用性

reaction type: solution phase peptide synthesis

顏色

white

mp

204 °C (dec.) (lit.)

應用

cell analysis

SMILES 字串

CC(C)(SSC(C)(C)[C@@H](N)C(O)=O)[C@@H](N)C(O)=O

InChI

1S/C10H20N2O4S2/c1-9(2,5(11)7(13)14)17-18-10(3,4)6(12)8(15)16/h5-6H,11-12H2,1-4H3,(H,13,14)(H,15,16)/t5-,6-/m0/s1

InChI 密鑰

POYPKGFSZHXASD-WDSKDSINSA-N

相关类别

應用

Used in pharmacological studies of:
  • Molecules dermatomyositis activity
  • Antimelanoma activity of apoptogenic carbonyl scavengers

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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Fabrizio Apruzzese et al.
Annali di chimica, 94(1-2), 45-56 (2004-05-15)
D-penicillamine disulfide (PNS) shows protolytic properties and is able to form complexes with cations, because it has two aminic groups and two carboxylic groups. The four protonation constants of its deprotonated species were determined by means of electromotive force (e.m.f.)
Anshul Gupte et al.
Journal of inorganic biochemistry, 101(4), 594-602 (2007-02-06)
D-Penicillamine is a potent copper (Cu) chelating agent. D-Pen reduces Cu(II) to Cu(I) in the process of chelation while at the same time being oxidized to D-penicillamine disulfide. It has been proposed that hydrogen peroxide is generated during this process.
[Determination of D-penicillamine and its metabolites in blood and urine].
K Kyogoku et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 102(4), 322-327 (1982-04-01)
Determination of penicillamine in encapsulated formulations by high-performance liquid chromatography.
S Biffar et al.
Journal of chromatography, 318(2), 404-407 (1985-01-18)
G T Yamashita et al.
Journal of chromatography, 491(2), 341-354 (1989-07-21)
Methodology is described for the simultaneous determination of D-penicillamine, penicillamine disulfide and the penicillamine-glutathione mixed disulfide, as well as glutathione and glutathione disulfide, in human plasma, erythrocytes and urine. The various thiols and disulfides are separated by reversed-phase ion-pairing liquid
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