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Merck

A75900

Sigma-Aldrich

1-氨基哌啶

97%

别名:

五亚甲基肼, 哌啶-1-基胺

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About This Item

经验公式(希尔记法):
C5H12N2
CAS号:
分子量:
100.16
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

97%

形狀

liquid

折射率

n20/D 1.475 (lit.)

bp

146 °C/730 mmHg (lit.)

密度

0.928 g/mL at 25 °C (lit.)

SMILES 字串

NN1CCCCC1

InChI

1S/C5H12N2/c6-7-4-2-1-3-5-7/h1-6H2

InChI 密鑰

LWMPFIOTEAXAGV-UHFFFAOYSA-N

應用

1-氨基哌啶可作为反应物与甲酸乙酯反应制得N-1-哌啶基甲酰胺。也与氢化铝、氢化镓反应生成相应的酰肼。在制药工业中,氨基哌啶被用作合成各种生物活性分子的构件。
用于合成以下物质的反应物:
  • CB1大麻素受体配体†
  • 腙类†
  • 四氢萘衍生物对LPS激活RAW 264.7巨噬细胞增殖和一氧化氮生成的影响
  • 磷(V)肼

其他說明

剩余哌啶

象形圖

FlameExclamation mark

訊號詞

Warning

危險分類

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

96.8 °F - closed cup

閃點(°C)

36 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Aluminum and gallium hydrazides derived from N-aminopyrrole and N-aminopiperidine
Uhl Werner, et al.
Zeitschrift fur Naturforschung B, 61(7), 854-861 (2006)
Thomas Lübbers et al.
Bioorganic & medicinal chemistry letters, 17(11), 2966-2970 (2007-04-10)
In a search for novel DPP-IV inhibitors, 2-aminobenzo[a]quinolizines were identified as submicromolar HTS hits. Due to the difficult synthetic access to this compound class, 1,3-disubstituted 4-aminopiperidines were used as model compounds for optimization. The developed synthetic methodology and the SAR
Fernando C Baltanás et al.
Biochimica et biophysica acta. Reviews on cancer, 1874(2), 188445-188445 (2020-10-10)
SOS1 and SOS2 are the most universal and widely expressed family of guanine exchange factors (GEFs) capable or activating RAS or RAC1 proteins in metazoan cells. SOS proteins contain a sequence of modular domains that are responsible for different intramolecular
Synthesis, structure- activity relationship, and evaluation of SR141716 analogues: Development of central cannabinoid receptor ligands with lower lipophilicity
Katoch-Rouse R, et al.
Journal of Medicinal Chemistry, 46(4), 642-645 (2003)
Inhibition of metabolism--mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma cells (line P815).
P Wiebkin et al.
Advances in experimental medicine and biology, 136 Pt B, 1067-1075 (1981-01-01)

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