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形狀
solid (could be powder/granules/chunks)
品質等級
分子量
PCL Mn 15,000
PEG average Mn 5,000
顏色
white to beige, light yellow
儲存溫度
2-8°C
應用
PEG-SS-PCL is a redox responsive, biocompatible, amphiphilic block copolymer composed of a hydrophilic poly(ethylene glycol) (PEG) block and a hydrophobic poly(ε-caprolactone) (PCL) block, with a reducible disulfide linkage between blocks. This polymer can be fabricated into Glutathione (GSH) responsive nanoparticles which can be used as an intracellular drug delivery system.
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
pH/redox dual-sensitive nanoparticles based on the PCL/PEG triblock copolymer for enhanced intracellular doxorubicin release.
Royal Society of Chemistry Advances, 5, 28060-28069 (2015)
Journal of controlled release : official journal of the Controlled Release Society, 260, 46-60 (2017-05-26)
The lack of efficient therapeutic options for many severe disorders including cancer spurs demand for improved drug delivery technologies. Nanoscale drug delivery systems based on poly(ethylene glycol)-poly(ε-caprolactone) copolymers (PEG-PCL) represent a strategy to implement therapies with enhanced drug accumulation at
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Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.
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