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Merck

925624

Sigma-Aldrich

Redox Responsive Poly(ethylene glycol)-block-poly(ε-caprolactone)

PEG average Mn 5,000, PCL Mn 15,000

别名:

Block copolymer, PEG-PCL with disulfide linkage, PEG-SS-PCL, Stimuli-responsive

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About This Item

线性分子式:
CH3O(C2H4O)nC7H12O4S2(C6H10O2)
分類程式碼代碼:
12352112
NACRES:
NA.23

形狀

solid (could be powder/granules/chunks)

品質等級

分子量

PCL Mn 15,000
PEG average Mn 5,000

顏色

white to beige, light yellow

儲存溫度

2-8°C

應用

PEG-SS-PCL is a redox responsive, biocompatible, amphiphilic block copolymer composed of a hydrophilic poly(ethylene glycol) (PEG) block and a hydrophobic poly(ε-caprolactone) (PCL) block, with a reducible disulfide linkage between blocks. This polymer can be fabricated into Glutathione (GSH) responsive nanoparticles which can be used as an intracellular drug delivery system.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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pH/redox dual-sensitive nanoparticles based on the PCL/PEG triblock copolymer for enhanced intracellular doxorubicin release.
Cao Y, et al.
Royal Society of Chemistry Advances, 5, 28060-28069 (2015)
Philip Grossen et al.
Journal of controlled release : official journal of the Controlled Release Society, 260, 46-60 (2017-05-26)
The lack of efficient therapeutic options for many severe disorders including cancer spurs demand for improved drug delivery technologies. Nanoscale drug delivery systems based on poly(ethylene glycol)-poly(ε-caprolactone) copolymers (PEG-PCL) represent a strategy to implement therapies with enhanced drug accumulation at

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