917974

BocA1V2PF2

• 别名: (S)-2-((S)-1-((S)-2-((S)-2-((tert-Butoxycarbonyl)amino)propanamido)-2-cyclohexylacetyl)pyrrolidine-2-carboxamido)-3-(4-fluorophenyl)propanoic acid, IAP E3 ligase lead for protein degrader research, SNIPER building block
• 经验公式（希尔记法）: C₃₀H₄₃FN₄O₇
• 分子量: 590.68
• MDL编号: MFCD34602220
• UNSPSC代码: 41116105
• NACRES: NA.22

属性

• ligand: BocA1V2PF2
• 质量水平: 100
• 表单: powder
• 反应适用性: reagent type: ligand
• 官能团: carboxylic acid
• 储存温度: 2-8°C
• SMILES字符串: C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CC=C(C=C2)F)=O)=O)C3CCCCC3)=O
• InChI: 1S/C30H43FN4O7/c1-18(32-29(41)42-30(2,3)4)25(36)34-24(20-9-6-5-7-10-20)27(38)35-16-8-11-23(35)26(37)33-22(28(39)40)17-19-12-14-21(31)15-13-19/h12-15,18,20,22-24H,5-11,16-17H2,1-4H3,(H,32,41)(H,33,37)(H,34,36)(H,39,40)/t18-,22-,23-,24-/m0/s1
• InChI key: LNJCHGKSSPMNRM-IMNFJDCFSA-N

说明

应用

BocA1V2PF2 is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlights. A C-terminal variant of BocA1V2PF2 is also available as A1V2PF2-NHEt (916714).

BocA1V2PF2 conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining
SNIPER and PROTAC^® degrader libraries: Degrader Building Blocks

917443BocA1V2PF2-NHC₆-NH2
917699 BocA1V2PF2-NHC₁₀-NH₂
917958 BocA1V2PF2-NHPEG₁-NH₂
916692 BocA1V2PF2-NHPEG₃-NH₂

其他说明

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs—Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable