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Merck

862304

Sigma-Aldrich

3,4-脱氢-L-脯氨酸

98%

别名:

(S)-3-吡咯啉-2-羧酸, 3,4-二脱氢-L-脯氨酸

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About This Item

经验公式(希尔记法):
C5H7NO2
CAS号:
分子量:
113.11
Beilstein:
5376764
EC 号:
MDL编号:
UNSPSC代码:
12352103

方案

98%

旋光性

[α]20/D −385°, c = 2 in H2O

mp

248-250 °C (lit.)

SMILES字符串

OC(=O)[C@H]1NCC=C1

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Hyuk Sung Kwon et al.
Bioorganic & medicinal chemistry letters, 21(14), 4325-4328 (2011-06-15)
Oxygen dependent degradation of hypoxia-inducible factor (HIF)-1α is triggered with hydroxylation by proline hydroxylase domain 2 (PHD2) under normoxic conditions. Some of previously developed PHD2 inhibitors show a considerable potency against factor inhibiting HIF (FIH), the HIF asparagine hydroxylase. For
Griet Van Zeebroeck et al.
Nature chemical biology, 5(1), 45-52 (2008-12-09)
Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting transceptors is unknown. We have screened 319 amino acid analogs to identify compounds that act on Gap1

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