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材料
PEG 5000
品質等級
形狀
dispersion in H2O
nanoparticles
成份
, 3.58E12 particles/mL
包裝
pkg of 0.5 mL
儲存條件
do not freeze
濃度
2.33 mg/mL in H2O
外徑
50
表面積
7.74 m2/g
直徑
40 nm
pH值
5-7
密度
1.00 g/cm3
peak SPR wavelength
530 nm
官能基
biotin
儲存溫度
2-8°C
InChI
1S/Au
InChI 密鑰
PCHJSUWPFVWCPO-UHFFFAOYSA-N
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一般說明
Gold nanoparticles PEG 5000 biotin terminated.The preparation of biotinylated gold nanoparticles involves two surface modification steps. First the carboxyl-terminated alkanethiol is attached to the surface of gold nanoparticles via chemisorption in the presence of a stabilizing agent. This step is followed by the reaction of the carboxyl groups with (+)-biotinyl-3,6,9,-trioxaundecanediamine and 2-(2-aminoethoxy)ethanol.
應用
Biotin functionalized gold nanoparticles are suitable for binding of streptavidin labelled conjugates. The gold nanoparticle label allows for straightforward detection of streptavidin by measuring the increase in absorbance of the sample upon binding. The absorption maximum is gold nanoparticle size dependent and ranges from 515-520nm for a 5nm particle to 572nm for a 100nm particle.
Gold nanoparticles 40 nm diameter, biotin terminated, PEG 5000 coated, OD 50, dispersion in H2O can be used as a theranostic agent for potential usage in cancer therapy and treatment of COVID-19. It can also be used in the detection of pathogens for biosensing applications. AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique.
法律資訊
Product of CytoDiagnostics, Inc.
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Controlled and reversible aggregation of biotinylated gold nanoparticles with streptavidin.
The Journal of Physical Chemistry B, 108(40), 15631-15639 (2004)
Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy
Biomaterials, 33(3), 856-866 (2012)
Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis
Journal of Medical Virology, 33(6), 666-680 (2020)
Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients
Theranostics, 10(13), 5932-5932 (2020)
Localized surface plasmon resonance (LSPR) of polyelectrolyte-functionalized gold-nanoparticles for bio-sensing
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 332(2-3), 172-179 (2009)
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