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Merck

808865

Sigma-Aldrich

金纳米颗粒

40 nm diameter, biotin terminated, PEG 5000 coated, OD 50, dispersion in H2O

别名:

Biotin Gold

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About This Item

分類程式碼代碼:
12141717
NACRES:
NA.23

材料

PEG 5000

品質等級

形狀

dispersion in H2O
nanoparticles

成份

, 3.58E12 particles/mL

包裝

pkg of 0.5 mL

儲存條件

do not freeze

濃度

2.33 mg/mL in H2O

外徑

50

表面積

7.74 m2/g

直徑

40 nm

pH值

5-7

密度

1.00 g/cm3

peak SPR wavelength

530 nm

官能基

biotin

儲存溫度

2-8°C

InChI

1S/Au

InChI 密鑰

PCHJSUWPFVWCPO-UHFFFAOYSA-N

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一般說明

Gold nanoparticles PEG 5000 biotin terminated.The preparation of biotinylated gold nanoparticles involves two surface modification steps. First the carboxyl-terminated alkanethiol is attached to the surface of gold nanoparticles via chemisorption in the presence of a stabilizing agent. This step is followed by the reaction of the carboxyl groups with (+)-biotinyl-3,6,9,-trioxaundecanediamine and 2-(2-aminoethoxy)ethanol.

應用

Biotin functionalized gold nanoparticles are suitable for binding of streptavidin labelled conjugates. The gold nanoparticle label allows for straightforward detection of streptavidin by measuring the increase in absorbance of the sample upon binding. The absorption maximum is gold nanoparticle size dependent and ranges from 515-520nm for a 5nm particle to 572nm for a 100nm particle.
Gold nanoparticles 40 nm diameter, biotin terminated, PEG 5000 coated, OD 50, dispersion in H2O can be used as a theranostic agent for potential usage in cancer therapy and treatment of COVID-19. It can also be used in the detection of pathogens for biosensing applications. AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique.

法律資訊

Product of CytoDiagnostics, Inc.

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Controlled and reversible aggregation of biotinylated gold nanoparticles with streptavidin.
Aslan K, et al.
The Journal of Physical Chemistry B, 108(40), 15631-15639 (2004)
Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy
Heo DN, et al.
Biomaterials, 33(3), 856-866 (2012)
Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis
Li Z, et al.
Journal of Medical Virology, 33(6), 666-680 (2020)
Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients
Itani R, et al.
Theranostics, 10(13), 5932-5932 (2020)
Localized surface plasmon resonance (LSPR) of polyelectrolyte-functionalized gold-nanoparticles for bio-sensing
Li X, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 332(2-3), 172-179 (2009)

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