材料
PEG 5000
形狀
dispersion in H2O
nanoparticles
包裝
poly bottle of 1 mL
外徑
50
直徑
10 nm
pH值
6.0-8.0 (25 °C)
溶解度
water: miscible
密度
1.00 g/cm3
官能基
methoxy
儲存溫度
2-8°C
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一般說明
Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields.They show excellent biocompatibility and attractive physicochemical properties. AuNPs, as aggregates, is shown to be highly sensitive colloidal biosensors. Poly (ethylene) glycol (PEG) surface coating on gold nanoparticles helps in the reduction of protein adsorption, reduces nonspecific interactions with cells and greatly improves the pharmokinetics of these nanoparticles and disables aggregation of the nanoparticles. AuNPs coated with PEG 5000 exhibited highest colloidal stability. The methyl group, being hydrophobic acts as a protecting shield between the gold nanoparticles and the hydrophilic outer PEG coating and also leads to a further reduction of protein adsorption and macrophage uptake by the AuNPs.
應用
Several other specific applications have been listed below:
- Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and may also be used in biodistribution studies.
- AuNPs may also be used in photothermal therapy and radiotherapy.
- AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen , when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
特點和優勢
PEG decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration. Forms complexes easily with dyes and thiol ligands.
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Size-dependent in vivo toxicity of PEG-coated gold nanoparticles
Zhang, X. D., Wu, D., Shen, X., Liu, P. X., Yang, N., Zhao, B., & Fan, F. Y.
International journal of nanomedicine, 6, 2071j-2071j (2011)
Timothy A Larson et al.
ACS nano, 6(10), 9182-9190 (2012-09-27)
Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. There is abundant literature on the benefits of PEG coatings and their ability to reduce protein adsorption, to diminish nonspecific interactions with cells
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)
商品
The recent emergence of a number of highly functional nanomaterials has enabled new approaches to the understanding, diagnosis, and treatment of cancer.
最近出现的许多高功能纳米材料为癌症的认识、诊断和治疗提供了新的方案。
Biomaterials science integrates smart materials into biological research, requiring a deep understanding of biological systems.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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