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Merck

731765

Sigma-Aldrich

聚乙二醇甲醚马来酰亚胺

average Mn 2,000, maleimide, methoxy, chemical modification reagent thiol reactive

别名:

PEG 甲醚马来酰亚胺, 甲氧基 PEG 马来酰亚胺

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About This Item

线性分子式:
CH3O(CH2CH2O)nCH2CH2OC(O)CH2CH2CH2N[C(O)]2CHCH
分類程式碼代碼:
12162002
NACRES:
NA.23

product name

聚乙二醇甲醚马来酰亚胺, average Mn 2,000

形狀

solid

分子量

average Mn 2,000

反應適用性

reagent type: chemical modification reagent
reactivity: thiol reactive

mp

48-52 °C

Mw/Mn

<1.1

Ω-end

maleimide

α-end

methoxy

聚合物結構

shape: linear
functionality: monofunctional

應用

聚(乙二醇)甲基醚马来酰亚胺是马来酰亚胺官能化的聚(乙二醇)。由于马来酰亚胺官能化,该材料可用于快速结合含硫醇的生物分子、API或靶向配体。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Karina L Heredia et al.
Macromolecules, 42(7), 2360-2367 (2009-01-01)
In this report we describe a straightforward approach to synthesize polymers with end-groups that bind site-specifically to two different proteins. Telechelic biotin, maleimide poly(N-isopropylacrylamide) (pNIPAAm) was synthesized for the formation of streptavidin (SAv)-bovine serum albumin (BSA) polymer conjugates. Reversible addition-fragmentation

商品

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

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