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About This Item
经验公式（希尔记法）:
C8H15NO2
CAS号:
分子量:
157.21
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
推荐产品
化驗
97%
形狀
liquid
密度
1.092 g/mL at 25 °C
SMILES 字串
CCOC(=O)[C@@H]1CCCNC1
InChI
1S/C8H15NO2/c1-2-11-8(10)7-4-3-5-9-6-7/h7,9H,2-6H2,1H3/t7-/m1/s1
InChI 密鑰
XIWBSOUNZWSFKU-SSDOTTSWSA-N
應用
Reactant for synthesis of:
Reactant for stereocontrolled hydoiodination of alkynes
Used for an orally potent anti-anxiety drug
- DPP-4 inhibitors
- Dual H1/5-HT2A receptor antagonists for treatment of sleep disorders
- Serotonin and noradrenaline reuptake inhibitors
- GABA uptake inhibitors
Reactant for stereocontrolled hydoiodination of alkynes
Used for an orally potent anti-anxiety drug
訊號詞
Danger
危險聲明
危險分類
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
219.2 °F
閃點（°C）
104 °C
個人防護裝備
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
M Potegal
Psychopharmacology, 89(4), 444-448 (1986-01-01)
The GABA uptake inhibitor ethyl (R,S)-nipecotate produces a dose-dependent suppression of aggression in highly aggressive hamsters but not in minimally aggressive ones. This suppression occurs at doses below those producing peripheral cholinergic effects; at the highest dose used it persists
S H Zorn et al.
The Journal of pharmacology and experimental therapeutics, 242(1), 173-178 (1987-07-01)
Previous reports have suggested that the ethyl ester of (R)-nipecotic acid ethyl ester [(R)-NAEE] displays cholinomimetic properties in vivo. The present study was undertaken to characterize more fully this action by examining the effects of (R)-NAEE in a number of
T Andree et al.
Life sciences, 32(19), 2265-2272 (1983-05-09)
THIP (4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridone-3-ol), a direct acting GABA receptor agonist, has been shown to have antinociceptive properties. To determine whether tolerance develops to the analgesic response, mice received multiple injections of THIP for up to 21 days after which analgesia
Wen-Juan Zhao et al.
Acta pharmacologica Sinica, 24(10), 991-995 (2003-10-09)
The changes of seizure susceptibility of transgenic mice overexpressing GABA transporter-1 (GAT-1) were studied to clarify the possible role of GABAergic transmission in epileptogenesis. Seizures were induced by intraperitoneal administration of pentylenetetrazol (PTZ), picrotoxin (PIC), or kainic acid (KA) respectively.
Jia-Hua Hu et al.
Journal of neuroscience research, 73(4), 565-572 (2003-08-05)
The present study focused on the involvement of gamma-aminobutyric acid transporter I (GAT1) in pain. We found that GABA uptake was increased in mouse spinal cord at 20 min and 120 min after formalin injection and in mouse brain at
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