440868

(R)-(+)-(3-氯苯基)环氧乙烷

98%

• 别名: (R)-(+)-(3-Chlorophenyl)oxirane
• 经验公式（希尔记法）: C₈H₇ClO
• CAS号: 62600-71-9
• 分子量: 154.59
• MDL號碼: MFCD00673317
• 分類程式碼代碼: 12352000

属性

• 化驗: 98%
• 光學活性: [α]20/D +21°, neat
• 折射率: n20/D 1.551 (lit.)
• bp: 67-68 °C/1 mmHg (lit.)
• 密度: 1.214 g/mL at 25 °C (lit.)
• SMILES 字串: Clc1cccc(c1)[C@@H]2CO2
• InChI: 1S/C8H7ClO/c9-7-3-1-2-6(4-7)8-5-10-8/h1-4,8H,5H2/t8-/m0/s1
• InChI 密鑰: YVMKRPGFBQGEBF-QMMMGPOBSA-N

说明

應用

Reactant involved in:

• Diastereoselective Wadsworth-Emmons cyclopropanation for synthesis of quaternaty cyclopropyl esters
• Synthesis of phenylethanolamine derivatives as β3-adrenergic receptor agonists
• Stereoselective ring-opening for synthesis of β-aryloxy-substituted alcohols and amines
• Synthesis of Biphenyl benzoic acid derivatives as β3-adrenergic receptor agonists
• Synthesis of (S)-2-, 3-, and 4-chlorostyrene oxides with epoxide hydrolase

重要的手性合成子，用于制备强效治糖尿病药和减肥药 CL-316,243，CL-316,243 是一种含苯并二茂的苯乙醇胺。该手性环氧化物与胺的开环反应可产生氨基醇类化合物，用作 β-肾上腺素激动剂。