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Merck

415936

Sigma-Aldrich

3,4-二氢-2(1H)-喹啉酮

98%

别名:

氢化喹诺酮

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About This Item

经验公式(希尔记法):
C9H9NO
CAS号:
分子量:
147.17
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

98%

mp

165-167 °C (lit.)

SMILES 字串

O=C1CCc2ccccc2N1

InChI

1S/C9H9NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-4H,5-6H2,(H,10,11)

InChI 密鑰

TZOYXRMEFDYWDQ-UHFFFAOYSA-N

一般說明

合成了一系列具有 sigma-1 受体(σ1R)拮抗剂活性的 3,4-二氢-2(1H)-喹啉酮衍生物。使用N-(1′-烷氧基)环丙基-2-卤代苯胺作为起始试剂合成了 3,4-二氢-2((1)H)-喹啉酮。在钯催化剂的存在下环丙烷环的扩环反应是合成的主要步骤。通过在固相上重排 β-内酰胺中间体合成了 3,4-二氢-2(1H)-喹啉酮的文库

應用

在富集培养实验中,可以将 3,4-二氢-2(1H)-喹啉酮用作在假单胞菌培养基中的培养基补充剂。

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Takayuki Tsuritani et al.
Organic letters, 11(5), 1043-1045 (2009-02-06)
N-(1'-Alkoxy)cyclopropyl-2-haloanilines are transformed to 3,4-dihydro-2((1)H)-quinolinones via palladium-catalyzed cyclopropane ring expansion. The reaction tolerates a variety of functional groups such as ester, nitrile, ether, and ketone groups.
Fabio Del Bello et al.
Journal of medicinal chemistry, 63(11), 5763-5782 (2020-05-07)
A series of novel 1,4-dioxane analogues of the muscarinic acetylcholine receptor (mAChR) antagonist 2 was synthesized and studied for their affinity at M1-M5 mAChRs. The 6-cyclohexyl-6-phenyl derivative 3b, with a cis configuration between the CH2N+(CH3)3 chain in the 2-position and
Synthesis of 4-amino-3, 4-dihydro-2 (1H)-quinolinones via β-lactam intermediates on the solid-phase.
Pei Y, et al.
Tetrahedron Letters, 38(19), 3349-3352 (1997)
So Youn Park et al.
Behavioural brain research, 365, 133-140 (2019-03-10)
Cerebrovascular dysfunction is associated with cognitive impairment in vascular dementia patients. This study aimed to explore augmented improvement of cognition and memory by aripiprazole add-on for cilostazol treatment in vascular dementia model. Male C57BL/6 mice were subjected to BCAS, and
Selective removal of nitrogen from quinoline and petroleum by Pseudomonas ayucida IGTN9m.
Kilbane JJ, et al.
Applied and Environmental Microbiology, 66(2), 688-693 (2000)

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