等級
technical grade
化驗
90%
mp
89-91 °C (lit.)
SMILES 字串
CCNC(=O)\C=C\c1cccc(Br)c1
InChI
1S/C11H12BrNO/c1-2-13-11(14)7-6-9-4-3-5-10(12)8-9/h3-8H,2H2,1H3,(H,13,14)/b7-6+
InChI 密鑰
LDCXGZCEMNMWIL-VOTSOKGWSA-N
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E A Lane et al.
Journal of pharmaceutical sciences, 72(5), 493-496 (1983-05-01)
Fifty percent of a cinromide dose was metabolized to an active metabolite in the rhesus monkey. The steady-state concentration of this metabolite was 3-6 times that of the parent drug, depending on the route of administration. Cinromide is a medium-extraction
A J Wilensky et al.
Epilepsia, 24(4), 401-409 (1983-08-01)
Monotherapy with the experimental antiepileptic drug cinromide was evaluated in 11 adult outpatients with uncontrolled partial epilepsy. They were treated with phenytoin for 2 months, cinromide for 4 months, and carbamazepine for 4 months. Four patients withdrew from the study
E A Lane et al.
Journal of pharmaceutical sciences, 72(11), 1352-1354 (1983-11-01)
The dose-dependent nonlinearity of the clearance of cinromide, a medium extraction ratio drug, has been established in two monkeys. Special problems encountered in evaluation of nonlinearity of such drugs were resolved by the experimental design: cinromide was infused to steady
Prediction of steady-state behavior of metabolite from dosing of parent drug.
E A Lane et al.
Journal of pharmaceutical sciences, 69(5), 610-612 (1980-05-01)
J W Allen et al.
Epilepsia, 24(4), 422-426 (1983-08-01)
A double-blind controlled trial of cinromide in 25 adult subjects with refractory epilepsy using the maximum tolerated dose showed that it possessed no significant antiepileptic properties.
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