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Merck

334618

Sigma-Aldrich

反-四氯二氨铂(IV)

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About This Item

线性分子式:
Pt(NH3)2Cl4
CAS号:
分子量:
370.95
MDL號碼:
分類程式碼代碼:
12352302

mp

>300 °C (lit.)

SMILES 字串

N.N.Cl[Pt](Cl)(Cl)Cl

InChI

1S/4ClH.2H3N.Pt/h4*1H;2*1H3;/q;;;;;;+4/p-4

InChI 密鑰

RBHOYUZKIANPPG-UHFFFAOYSA-J

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A C Plooy et al.
Cancer research, 44(5), 2043-2051 (1984-05-01)
Several effects of four diamminechloroplatinum compounds (II and IV) in Chinese hamster ovary cells were studied. The two cis-compounds [cis-diamminedichloroplatinum(II) and cis-diamminetetrachloroplatinum(IV)] are known to possess antitumor activity, whereas the two trans-stereoisomers [trans-diamminedichloroplatinum(II) and trans-diamminetetrachloroplatinum(IV)] are inactive. When the effects
M Defais et al.
Chemico-biological interactions, 74(3), 343-352 (1990-01-01)
DNA strand breaks were observed in bacteria treated with Pt(IV) but not Pt(II) antitumor compounds by two methods. First, compounds which cause DNA strand breaks produced an SOS induction signal which was detected by a rapid bacterial assay. In addition
H Razaka et al.
Chemico-biological interactions, 60(2), 207-215 (1986-11-01)
After exposure of bacteria to equal concentrations of cis-diamminedichloroplatinum(II) (DDP) and cis-diamminetetrachloroplatinum(IV) (DTP), the intracellular concentration of DTP was an order of magnitude greater than DDP. However, at identical intracellular drug concentrations, the Pt(IV) compound formed only half as many

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