推荐产品
化驗
99%
mp
220-223 °C (lit.)
SMILES 字串
OC1CN2CC[C@H]1CC2
InChI
1S/C7H13NO/c9-7-5-8-3-1-6(7)2-4-8/h6-7,9H,1-5H2
InChI 密鑰
IVLICPVPXWEGCA-UHFFFAOYSA-N
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一般說明
(R)-3-Quinuclidinol is a valuable compound for the production of various pharmaceuticals.
應用
用于制备胆碱能受体配体和麻醉剂的合成子。用于醛类与甲基乙烯基酮缩合的催化剂。
訊號詞
Danger
危險聲明
危險分類
Skin Corr. 1B
儲存類別代碼
8A - Combustible corrosive hazardous materials
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Organic letters, 15(19), 4917-4919 (2013-09-21)
A new keto reductase (ArQR), identified from Agrobacterium radiobacter ECU2556, can efficiently reduce 3-quinuclidinone in excellent enantioselectivity and high space-time yield for the synthesis of (R)-3-quinuclidinol, a chiral building block of many antimuscarinic agents. This is the first time that
Selective Cleavage of ?-Keto and Vinylogous ?-Keto Esters by 3-Quinuclidinol.
Synthetic Communications, 5(5), 341-345 (1975)
Journal of medicinal chemistry, 34(10), 2989-2993 (1991-10-01)
Seven analogues of 3-quinuclidinyl benzilate (QNB) in which one phenyl ring was replaced by an alkoxyalkyl moiety were synthesized and their affinities for the muscarinic cholinergic receptor determined. An oxygen in the beta-position of the moiety was not well-tolerated. By
Synthesis and local anaesthetic activities of 3-(2-alkoxyphenylcarbamoyloxy)chinuclidinium chlorides.
Die Pharmazie, 48(6), 465-466 (1993-06-01)
Khim.-Farm. Zh., 26, 12-12 (1992)
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