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Merck

15719

Sigma-Aldrich

D -甘露醇

meets analytical specification of Ph. Eur., USP, FCC, E421, 98.0-101.5% (calc. to the dried substance, HPLC)

别名:

甘露糖醇

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About This Item

经验公式(希尔记法):
C6H14O6
CAS号:
分子量:
182.17
Beilstein:
1721898
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:

方案

98-102% (calc. to dried substance)
98.0-101.5% (calc. to the dried substance, HPLC)

旋光性

[α]20/D +23 to +25°, c = 8% in Na2B4O7
[α]25/D +137 to +145

质量

meets analytical specification of Ph. Eur., USP, FCC, E421

杂质

acidity or alcalinity, complies
reducing sugars, complies
related substances, in accordance (HPLC)
residual solvents, complies
sorbit (DC), complies
≤0.007% free acid (as CH3COOH)
≤0.5% water (Karl Fischer)

灼烧残渣

≤0.1% (as SO4)

缺失

≤0.3% loss on drying, 105 °C, 4 h

pH值(酸碱度)

5-7.5 (20 °C, 10%)

电导率

20 μS/cm at 20 °C

mp

165-169 °C
167-170 °C (lit.)

痕量阴离子

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤100 mg/kg

痕量阳离子

As: ≤1 mg/kg
Cu: ≤10 mg/kg
Ni: ≤1 mg/kg
Zn: ≤10 mg/kg

适用性

complies for appearance of solution
passes test for identity (IR)

SMILES字符串

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

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生化/生理作用

一种糖醇类甜味剂。 用于甜味抑制研究。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Heikki O Koskela et al.
Chest, 124(6), 2171-2177 (2003-12-11)
To compare a new bronchial provocation test, the mannitol challenge, with cold air and histamine challenges to demonstrate airway hyperresponsiveness (AHR) in patients with difficult-to-diagnose asthma. A prospective study. Thirty-seven consecutive patients with recently diagnosed, steroid-naive, mild, or atypical asthma
Maria Badal Tejedor et al.
International journal of pharmaceutics, 486(1-2), 315-323 (2015-04-07)
Tablets are the most convenient form for drug administration. However, despite the ease of manufacturing problems such as powder adhesion occur during the production process. This study presents surface and structural characterization of tablets formulated with commonly used excipients (microcrystalline
Heikki O Koskela et al.
Chest, 125(6), 1985-1992 (2004-06-11)
To define whether coughing during mannitol challenge is a nonspecific side effect of this challenge or is associated with asthma. A prospective study. University hospital. Thirty-seven steroid-naive, asthmatic subjects and 10 healthy subjects. The participants completed a symptom questionnaire, recorded
Heikki O Koskela et al.
Chest, 124(4), 1341-1349 (2003-10-14)
To compare the sensitivity and validity of mannitol, histamine, and cold air challenges to demonstrate the effect of inhaled corticosteroids (ICS) in asthma. A prospective study. Seventeen patients with recently diagnosed, steroid-naive asthma who fulfilled the diagnostic criteria of Finnish
Diana Bilton et al.
Thorax, 69(12), 1073-1079 (2014-09-24)
Bronchiectasis is characterised by excessive production of mucus and pulmonary exacerbations. Inhaled osmotic agents may enhance mucociliary clearance, but few long-term clinical trials have been conducted. To determine the impact of inhaled mannitol on exacerbation rates in patients with non-cystic

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