Bioreactors for Fed-Batch and Perfusion Upstream Processes
Future-Proof Your Process with Modular Flexibility Today
Mobius® iFlex Bioreactors for upstream processes
The Mobius® iFlex Bioreactor takes modular flexibility, scalability, ergonomics, and convenience to the next level while adding next-generation performance and productivity.
Pipelines are diversifying, new therapeutic modalities are emerging, and demands for efficiency and productivity are increasing. To respond to these opportunities and challenges, today and in the future, manufacturers need the upstream flexibility of a traditional fed-batch bioreactor system with the ability to evolve to perfusion processes.
Access Next Generation Benefits for your Upstream Workflow Today
Mobius® iFlex Bioreactors are scalable from 50 L to 2000 L and incorporate innovative features for cell culture, including:
- A modular design, with a bioreactor vessel, fed-batch tower, perfusion tower, and control station that can be combined to suit your upstream process needs
- 5:1 turndown ratio for 200 L – 2000 L bioreactors (3.3:1 for 50 L), for flexible seeding and cell growth strategies
- An optimized bottom-mounted impeller design allows fast mixing times and higher power density, minimizing tip speed and mechanical shear
- An internal X-baffle for superior homogeneous mixing
- Three different spargers integrated in all single-use bag assemblies, providing unparalleled oxygen transfer.
Discover the Mobius® iFlex Bioreactor for Fed-Batch and Perfusion Culture
The Mobius® iFlex Bioreactor is a next-generation, single-use, modular bioreactor meticulously engineered for optimal performance in both batch and perfusion processes. It offers flexibility to integrate into a standard DeltaV-based automation or into your automation of choice.
In its fed-batch configuration, the system is composed of a bioreactor vessel, a fed-batch tower, and a control station, integrating all the sensors your upstream process requires for monitoring and control of critical process parameters. The bioreactor vessel and the fed-batch tower can be configured to suit your specific process requirements and offers the scalability, robustness, and reliability you expect from Mobius® Bioreactors.
Seamless Transition from Batch to Perfusion Processes
As your processes evolve toward intensified and continuous upstream processes, you can seamlessly transition into a perfusion process by adding a perfusion tower.
Working in unison with our Cellicon® filter assemblies, the Mobius® iFlex Bioreactor enables perfusion processes with a unique, ergonomic single-use design that supports ultra-high cell densities. To support high cell densities which require increased oxygen, our innovative single-use spargers, X-baffle and bottom-mounted impeller work together to provide unparalleled oxygen transfer with minimal cell shear.
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Related Product Resources
- Datasheet: Mobius® iFlex Bioreactor
The Mobius® iFlex Bioreactor is a scalable family of next generation high-performance single-use modular bioreactors for fed-batch and perfusion processes, ranging from 50 L to
2000 L, and suitable for process development and commercial manufacturing. - Article: Scalability and Performance of Mobius® iFlex Bioreactors
This page summarizes several performance attributes and scalability data for Mobius® iFlex Bioreactors, single-use, stirred tank systems designed to support traditional and intensified fed-batch and perfusion cell culture applications.
- Application Note: Scalability from Mobius® 3 L Single-Use Bioreactor to 50 L – 2000 L Mobius® iFlex Bioreactors to support intensified upstream process development
Scalability from Mobius® 3 L Single-Use Bioreactor to 50 L – 2000 L Mobius® iFlex Bioreactors to support intensified upstream process development
- White Paper: Investigation of increasing poloxamer 188 concentrations on bubble size, volumetric mass transfer, and foam generation to enable intensified bioreactor processes
Intensified bioreactor processes create a need to use higher efficiency sparging systems to keep up with increased oxygen demand. In this work, the hydrodynamics within bench (3 L) and pilot scale (200 L) bioreactors were explored.
- Ultimus® Film: Single-use Bioprocessing
Ultimus® Film is an innovative single-use bioprocessing film offering strength and leak resistance, available in Mobius® 3D bioprocess bags, it provides a stronger, more durable solution for your single-use manufacturing challenges.
- White paper: A comparative analysis of mixing characterization methods in stirred tanks
A homogenous environment and a rapid response to changing conditions are key requirements for a bioreactor. It is important to choose a method that will provide the highest quality data and enable effective cross-system comparison of results.
- Spare Parts List: Mobius® iFlex Bioreactor
This illustrated spare parts list will help you identify which parts to keep in stock.
- Article: Influence of Cell Specific Parameters in a Dielectric Spectroscopy Conversion Model Used to Monitor Viable Cell Density in Bioreactors
In the biopharmaceutical industry, the use of mammalian cells to produce therapeutic proteins is becoming increasingly widespread. Monitoring of these cultures via different analysis techniques is essential to ensure a good quality product while respecting good manufacturing practice (GMP) regulations.
- Process Analytical Technologies (PAT)
Process Analytical Technology (PAT) is a regulatory framework initiated by the United States’ Food and Drug Administration (FDA) that encourages innovation in pharmaceutical development, manufacturing, and quality assurance.
- Biopharma 4.0: Digital Transformation
Bioprocessing 4.0 integrates advanced technologies for future biomanufacturing facilities.
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