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UC441

Sigma-Aldrich

6´,-7´-Dihydroxybergamottin

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About This Item

Empirical Formula (Hill Notation):
C21H24O6
CAS Number:
145414-76-2
Molecular Weight:
372.41
MDL number:
MFCD01310683
UNSPSC Code:
12161501
PubChem Substance ID:
329827670
NACRES:
NA.77

form

solid

color

white to light beige

solubility

ethanol: soluble

storage temp.

2-8°C

SMILES string

C\C(CCC(O)C(C)(C)O)=C/COc1c2C=CC(=O)Oc2cc3occc13

InChI

1S/C21H24O6/c1-13(4-6-18(22)21(2,3)24)8-10-26-20-14-5-7-19(23)27-17(14)12-16-15(20)9-11-25-16/h5,7-9,11-12,18,22,24H,4,6,10H2,1-3H3/b13-8+

InChI key

IXZUPBUEKFXTSD-MDWZMJQESA-N

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Application

6′,7′-dihydroxybergamottin has been used to study its effect on the inhibition of cytochrome P450 (CYP)-mediated triazolam hydroxylation in dog liver microsomes.

Biochem/physiol Actions

CYP3A4 inhibitor.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

6′,-7′-Dihydroxybergamottin is soluble in ethanol and can be further diluted with water.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M J Hanley et al.
Journal of veterinary pharmacology and therapeutics, 33(2), 189-195 (2010-05-07)
Coadministration of grapefruit juice (GFJ) has been proposed to enhance the systemic availability and decrease the required dose of drugs such as cyclosporine that are extensively metabolized in the intestine and liver. Although GFJ inhibits human cytochrome P450 (CYP) 3A

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