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SML3801

Sigma-Aldrich

Trospium chloride

≥98% (HPLC)

Synonym(s):

(1α,3β,5α)-3-[(hydroxydiphenylacetyl)oxy]spiro[8-azoniabicyclo[3.2.1]octane-8,1’-pyrrolidinium] chloride, Azoniaspiro(3α-benziloyloxynortropane-8,1′-pyrrolidine) chloride

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About This Item

Empirical Formula (Hill Notation):
C25H30NO3·Cl
CAS Number:
Molecular Weight:
427.96
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

Biochem/physiol Actions

Trospium chloride is a peripheral muscarinic receptor antagonist that relaxes the smooth muscle in the bladder. It does ot cause central nervous system side effects typical for other drugs of its class. Trospium chloride is used for the treatment of overactive bladder.

Caution

Hygroscopic

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cognitive Effects of Anticholinergic Load in Women with Overactive Bladder
Clinical Interventions in Aging, 15, 1493-1503 (2020)
Trospium chloride improves overactive bladder symptoms: a multicenter phase III trial
The Journal of Urology, 171(6 Pt 1), 2311-2315 (2004)
Kelly Biastre et al.
The Annals of pharmacotherapy, 43(2), 283-295 (2009-02-06)
To review the pharmacology, pharmacokinetics, safety, and clinical application of trospium chloride for the management of overactive bladder (OAB). Clinical literature including both primary sources and review articles was accessed through MEDLINE, International Pharmaceutical Abstracts, and Cochrane databases from 1980

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