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SML1087

Sigma-Aldrich

Sumanirole maleate

≥98% (HPLC)

Synonym(s):

(5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate, (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate, CID 9818479 maleate, PNU-95,666 maleate

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About This Item

Empirical Formula (Hill Notation):
C11H13N3O · C4H4O4
CAS Number:
179386-44-8
Molecular Weight:
319.31
MDL number:
MFCD09832637
UNSPSC Code:
12352200
PubChem Substance ID:
329825464
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -22 to -32°, c = 1 in H2O

storage condition

desiccated

color

white to beige

solubility

H2O: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1N(C[C@H](NC)C2)C3=C2C=CC=C3N1.O=C(O)/C=C\C(O)=O

InChI

1S/C11H13N3O.C4H4O4/c1-12-8-5-7-3-2-4-9-10(7)14(6-8)11(15)13-9;5-3(6)1-2-4(7)8/h2-4,8,12H,5-6H2,1H3,(H,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-/t8-;/m1./s1

InChI key

VOJRMYBBPKNLLI-ORHWHDKWSA-N

Application

Sumanirole maleate has been used as a dopamine type 2 receptor (D2R) agonist to study its effects on spatial learning and memory in rats.

Biochem/physiol Actions

Sumanirole is a highly selective and potent dopamine D2 receptor agonist that decreased plasma prolactin levels and depressed dopamine neuron firing rates in the substantia nigra pars compacta. Sumanirole potently stimulates locomotor activity in in animal models of Parkinson′s disease.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Matthew F Lazenka et al.
The Journal of pharmacology and experimental therapeutics, 362(1), 14-23 (2017-04-16)
Clinically significant pain often includes a decrease in both behavior and mesolimbic dopamine signaling. Indirect and/or direct dopamine receptor agonists may alleviate pain-related behavioral depression. To test this hypothesis, the present study compared effects of indirect and direct dopamine agonists
Spatial working memory in male rats: pre-experience and task dependent roles of dopamine D1-and D2-like receptors
Bezu M, et al.
Frontiers in Behavioral Neuroscience, 11, 196-196 (2017)
Dopamine type 1-and 2-like signaling in the modulation of spatial reference learning and memory
Feyissa D D, et al.
Behavioural Brain Research, 362, 173-180 (2019)
Anna Niewiarowska-Sendo et al.
Biochimica et biophysica acta, 1864(10), 1855-1866 (2017-08-02)
In recent years a wide range of studies have shown that G protein-coupled receptors modulate a variety of cell functions through the formation of dimers. For instance, there is growing evidence for the dimerization of bradykinin or dopamine receptors, both
L Lencesova et al.
Life sciences, 191, 186-194 (2017-10-22)
Haloperidol is an antipsychotic agent and acts as dopamine D2 receptor (D2R) antagonist, as a prototypical ligand of sigma1 receptors (Sig1R) and it increases expression of type 1 IP We used differentiated NG-108 cells and H9c2 cells. Gene expression, Western
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