SML0265

BIP-135

≥95% (HPLC)

• Synonym(s): 3-(5-bromo-1-methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
• Empirical Formula (Hill Notation): C₂₁H₁₃BrN₂O₃
• CAS Number: 941575-71-9
• Molecular Weight: 421.24
• MDL number: MFCD16495779
• UNSPSC Code: 12352202
• PubChem Substance ID: 329825273
• NACRES: NA.77

Properties

• Assay: ≥95% (HPLC)
• form: powder
• color: light orange to dark orange
• solubility: DMSO: ≥15 mg/mL
• storage temp.: room temp
• SMILES string: Cn1cc(C2=C(C(=O)NC2=O)c3coc4ccccc34)c5cc(Br)ccc15
• InChI: 1S/C21H13BrN2O3/c1-24-9-14(13-8-11(22)6-7-16(13)24)18-19(21(26)23-20(18)25)15-10-27-17-5-3-2-4-12(15)17/h2-10H,1H3,(H,23,25,26)
• InChI key: QKQJCKAXFJBYKJ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BIP-135 is a potent inhibitor of glycogen synthase kinase-3 (GSK3) found to be relatively selective for GSK-3β (21 nM) over GSK-3α with modest activity toward PKCβ (β1: 980 nM; β2: 219 nM), DYRK1B (590 nM), and PI3Kα (870 nM). BIP-135 was found to be a superior neuroprotective agent in a cortical neuron model of oxidative stress over other GSK-3 inhibitors, such as AR-A011418 and SB216763. In a mouse model of spinal muscular atrophy (SMA), BIP-135 elevated SMN protein levels in vitro and extended median survival.

Potent GSK3 inhibitor; neuroprotective

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable