SAE2001
SARS-COV-2-Spike-RBD epitope (450-469)
≥95% (HPLC), lyophilized powder
Synonym(s):
COVID-19 epitope, Immune response epitope, SARS-COV-2 Spike protein peptide
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
Quality Level
form
lyophilized powder
solid
species reactivity
viral
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
SARS coronavirus ... S(43740568)
General description
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or (2019-nCoV) is a novel coronavirus first identified in December 2019, which has since infected millions of people worldwide.1 The Spike protein (also known as S protein) is the most studied of the coronaviruses proteins, since it contains the Receptor-Binding-Domain (RBD) for the ligand on the host cell membrane (the ACE2 protein), and also has epitopes recognized by T and B cells.
Specificity
SARS-COV-2-Spike-RBD epitope (450-469) is a synthetic peptide corresponding to the amino acid sequence of Spike RBD region (GeneID: QHD43416.1) in positions 450-469.Peptides derived from the SARS-COV-2-Spike-RBD protein can be recognized by anti-SARS-CoV-2-Spike protein antibodies.
Immunogen
S450-469: nylyrlfrksnlkpferdis
Application
The peptide may be used in various immunochemical techniques including Immunoblotting and Elisa.
Biochem/physiol Actions
The Spike protein (also known as S protein) is a type I trimeric glycoprotein that is presented on the virion membrane, giving it the appearance of a crown. The protein has two subunits: S1, or bulb, that contains the RBD3-10; and S2, or stalk, responsible for the fusion of the virion with the host cell membrane. The main receptor for SARS-CoV and SARS-CoV-2 on the membrane of the target cells is the Angiotensin 2 Converting Enzyme (ACE2), a metallopeptidase present on the membrane of many cells, including type-I and -II pneumocytes, small intestine enterocytes, kidney proximal tubules cells, the endothelial cells of arteries and veins, and the arterial smooth muscle, among other tissues.15-17
Physical form
Supplied as a lyophilized powder.Purity: ≥95% (HPLC)
Storage and Stability
Store the product at −20 °C. After initial thawing, it is recommended to store the peptide in working aliquots at −20 °C. Recommended thawing solution: Water.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.Data presented is the available current product information and provided as-is. This product has not been tested or verified in any additional applications, sample types, including any clinical use. Experimental conditions must be empirically derived by the user. Our Antibody Guarantee only covers tested applications stated herein and conditions presented in our product information and is not extended to publications.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients.
Bao-Zhong Zhang et al.
Cell research, 30(8), 702-704 (2020-07-03)
Xin Zou et al.
Frontiers of medicine, 14(2), 185-192 (2020-03-15)
It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2). Moreover, lung cells that have ACE2 expression may be the main target cells during
Zhixin Liu et al.
Journal of medical virology, 92(6), 595-601 (2020-02-27)
From the beginning of 2002 and 2012, severe respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) crossed the species barriers to infect humans, causing thousands of infections and hundreds of deaths, respectively. Currently, a novel coronavirus (SARS-CoV-2)
Chunyan Yi et al.
Cellular & molecular immunology, 17(6), 621-630 (2020-05-18)
Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotensin-converting enzyme 2 (ACE2) via the receptor-binding domain (RBD), and thus is
Jun Lan et al.
Nature, 581(7807), 215-220 (2020-04-01)
A new and highly pathogenic coronavirus (severe acute respiratory syndrome coronavirus-2, SARS-CoV-2) caused an outbreak in Wuhan city, Hubei province, China, starting from December 2019 that quickly spread nationwide and to other countries around the world1-3. Here, to better understand the
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