SAB4200160

Anti-Synaptotagmin 7 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(s): Anti-IPCA-7, Anti-PCANAP7, Anti-SYT-VII, Anti-SYT7
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~45 kDa
• species reactivity: mouse, human
• enhanced validation: recombinant expression; Learn more about Antibody Enhanced Validation
• concentration: ~1.0 mg/mL
• technique(s): western blot: 1-2 μg/mL using mouse brain extracts (S1 fraction) and HEK-293T cell lysates expressing human synaptotagmin 7
• UniProt accession no.: O43581
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... SYT7(9066) ; mouse ... Syt7(54525)

Description

General description

Synaptotagmin 7, also known as Syt7, is a transmembrane Ca²⁺ binding protein. It belongs to synaptotagmin family of proteins. Syt7 contains a single transmembrane domain, a variable linker sequence and C2A and C2B Ca²⁺-binding domains. Syt7 is ubiquitously expressed during development but is later restricted to dividing cells, postmitotic neurons and neuroendocrine cells.

Application

Anti-Synaptotagmin 7 antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Synaptotagmins regulates membrane or vesicular trafficking, including synaptic vesicle (SV) exocytosis. Synaptotagmin 7 plays a vital role in regulation of Ca²⁺-dependent lysosome exocytosis. Syt7 is expressed in pancreatic β-cells and has been suggested to function as a Ca²⁺ sensor regulating insulin secretion. Knockout of Syt7 in mice results in impaired insulin secretion and glucose intolerance.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable