![[Leu15]-Gastrin I human ≥95% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/153/342/d4cb3dd7-13f1-46cf-8d1f-3907a5de7a83/640/d4cb3dd7-13f1-46cf-8d1f-3907a5de7a83.png)
When reconstituted in DMSO at 10 mg/mL, stock solutions are stable for up to 6 months when stored in aliquots at -20°C. Avoid repeated freeze/thaw cycles.
S7067
SB 202190
≥98% (HPLC), powder, p38 MAP kinase inhibitor
Synonym(s):
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
Sign Into View Organizational & Contract Pricing
All Photos(3)
Select a Size
Change View
5 MG
$308.00
25 MG
$1,190.00
About This Item
Empirical Formula (Hill Notation):
C20H14FN3O
CAS Number:
Molecular Weight:
331.34
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Product Name
SB 202190, ≥98% (HPLC)
Quality Level
Assay
≥98% (HPLC)
form
powder
color
faintly yellow, to beige
solubility
DMSO: 10 mg/mL, clear
originator
GlaxoSmithKline
storage temp.
2-8°C
SMILES string
Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
InChI
1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
InChI key
QHKYPYXTTXKZST-UHFFFAOYSA-N
Gene Information
human ... MAPK14(1432)
General description
SB202190 aids in enhancing the self-renewal ability of neural stem cells fromNPC1-deficient mice.[1]
Application
SB 202190 has been used:
- to investigate the role of p38mitogen-activated protein kinase (MAPK) signaling in establishment of reovirus infection[2]
- as a p38α inhibitor in in vivo studies to study its impact on the development or progression of adenocarcinoma in the colon mucosa tissues of APC Min/+ mice.[3]
- as a component of basic BC medium to culture basal progenitor cells.[4]
- as a component of normal endometrium and endometrial tumor media for organoid culture.[5]
SB 202190 was used to inhibit p38 activation in MCF7 cells5, mouse macrophages6 and HepG2 cells.7
Biochem/physiol Actions
SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase. SB 202190 binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms.
Features and Benefits
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Protocol for generating airway organoids from 2D air liquid interface-differentiated nasal epithelia for use in a functional CFTR assay
Rodenburg LW, et al.
STAR protocols, 4(3), 102337-102337 (2023)
Uncoupling p38? nuclear and cytoplasmic functions and identification of two p38? phosphorylation sites on ?-catenin: implications for the Wnt signaling pathway in CRC models
Lepore Signorile M, et al.
Journal of Separation Science, 13(1), 223-223 (2023)
Shauna M Crowley et al.
PLoS pathogens, 16(4), e1008498-e1008498 (2020-04-14)
We investigated the role of the inflammasome effector caspases-1 and -11 during Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells (IECs). Salmonella burdens were significantly greater in the intestines of caspase-1/11 deficient (Casp1/11-/-), Casp1-/- and Casp11-/- mice, as
NPC1 gene deficiency leads to lack of neural stem cell self-renewal and abnormal differentiation through activation of p38 mitogen-activated protein kinase signaling
Yang SR, et al.
Journal of Separation Science, 24(2), 292-298 (2006)
p38 Mitogen-Activated Protein Kinase Signaling Enhances Reovirus Replication by Facilitating Efficient Virus Entry, Capsid Uncoating, and Postuncoating Steps
Mohamed A, et al.
American journal of virology, 97(2), e0000923-e0000923 (2023)
-
此试剂配制为溶液后储存温度是多少，可以储存多久？
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
