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S5761
Sodium bicarbonate
Sodium bicarbonate
powder, BioReagent, for molecular biology, suitable for cell culture, suitable for insect cell culture
Synonym(s):
Sodium hydrogen carbonate, soda bicarbonate
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500 G
$121.00
1 KG
$197.00
5 KG
$671.00
About This Item
Linear Formula:
NaHCO3
CAS Number:
Molecular Weight:
84.01
Beilstein:
4153970
EC Number:
MDL number:
UNSPSC Code:
12161702
PubChem Substance ID:
NACRES:
NA.75
Assay:
99.5-100.5%
grade:
for molecular biology
form:
powder
solubility:
water: soluble 100 mg/mL
Recommended Products
grade
for molecular biology
Quality Level
product line
BioReagent
Assay
99.5-100.5%
form
powder
quality
300
technique(s)
cell culture | insect: suitable
cell culture | mammalian: suitable
pH
6.8-7.4
pKa (25 °C)
(1) 6.37, (2) 10.25 (carbonic acid)
solubility
water: soluble 100 mg/mL
density
2.16 g/mL at 25 °C (lit.)
SMILES string
[Na+].OC([O-])=O
InChI
1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
InChI key
UIIMBOGNXHQVGW-UHFFFAOYSA-M
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General description
Sodium bicarbonate is broadly used as a physiological buffer in cell culture applications. The pKa for bicarbonate <-> carbonic acid reaction is 6.4 The pKa for bicarbonate <-> carbonate reaction is 10.3. Sodum bicarbonate has two pKas, 6.4 and 10.3. It is broadly used as an physiological buffer in in vitro applications.
Application
Sodium bicarbonate has been used:
- as a component of bovine embryo culture system during in vitro maturation, fertilization, and culture (IVMFC)[1]
- as a component of a 1:1 mixture of Dulbecco′s modified Eagle′s medium and Ham′s nutrient mixture F-12 during the culture of bovine microvascular endothelial cells[2]
- as a component of ITS (insulin transferrin and selenite) medium used during the isolation of dopamine neurons from human embryonic stem cells[3]
- as a component of medium used for cell culture of human embryonic kidney cells[4]
- as a component of Beltsville thawing solution used for the dilution of semen[5]
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Nonylphenols (NP) are ubiquitous substances that have been detected in highly diverse foodstuff. As breakdown products of nonylphenol ethoxylates, NP could end up in the aquatic environment. This article presents a rapid method for NP detection in surface water by planar solid phase extraction – planar yeast estrogen screen (pSPE-pYES).
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What is the shelf life after delivery and opening? Is there usually an impact on quality after 2 years? The color of the medium changed and the pH decreased. Does the solubility or function of sodium bicarbonate decrease as it gets older?
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This product is not assigned an expiration date. It is assigned a recommended retest date of approximately 5 years after the quality release date. A recommended retest date is the period of time during which the product is expected to remain within established stability specifications, provided that it has been stored under defined conditions. After the Retest Date, product samples should be examined to ensure that the product is still in compliance with the established specifications. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services.
After opening, various factors may influence the performance of the product. Moisture uptake and cross-contamination are common issues that are dependent on product handling and storage. If the product you are using is experience stability issues before the recommended restest date, this reporting should be investigated by our Technical Service team who can assist you with further troubleshooting and/or investigation. We kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice, click on "Report Product Issues" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.
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