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R9157

Sigma-Aldrich

Ro 4-1284

≥98% (HPLC)

Synonym(s):

2-Hydroxy-2-ethyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,5,6,7-hexahydrobenzo[a]chinolizine

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About This Item

Empirical Formula (Hill Notation):
C21H33NO3
CAS Number:
303-75-3
Molecular Weight:
347.49
MDL number:
MFCD01663028
UNSPSC Code:
12352200
PubChem Substance ID:
329824045

Assay

≥98% (HPLC)

form

solid

solubility

DMSO: 16 mg/mL

originator

Roche

storage temp.

2-8°C

SMILES string

CCC1(O)CC2N(CCc3cc(OC)c(OC)cc23)CC1CC(C)C

InChI

1S/C21H33NO3/c1-6-21(23)12-18-17-11-20(25-5)19(24-4)10-15(17)7-8-22(18)13-16(21)9-14(2)3/h10-11,14,16,18,23H,6-9,12-13H2,1-5H3

InChI key

TUNMGCULOKMBNJ-UHFFFAOYSA-N

Biochem/physiol Actions

Ro 4-1284 is a reversible VMAT2 inhibitor.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H400

Precautionary Statements

P273

Hazard Classifications

Aquatic Acute 1

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J E Leysen et al.
European journal of pharmacology, 206(1), 39-45 (1991-01-25)
[3H]Ketanserin was found to label (besides a low amount of 5-HT2 receptors) non-serotonergic binding sites on human platelet membranes. The latter binding was detected in the presence of excess of the 5-HT2 antagonist BW501, and was potently inhibited by tetrabenazine.
A M Dopico et al.
Journal of neurochemistry, 61(2), 481-489 (1993-08-01)
A single dose of x-irradiation was applied on the cephalic end of newborn rats, and the alterations in the noradrenergic afferents to the cerebellum were studied 180 days later. A net increase in the noradrenaline content of cerebellum was found
Innately hearing impaired Sprague-Dawley rats exhibit audiogenic seizure susceptibility following monoamine depletion.
C E Reigel et al.
Proceedings of the Western Pharmacology Society, 36, 267-271 (1993-01-01)
E Schömig et al.
Naunyn-Schmiedeberg's archives of pharmacology, 342(2), 160-170 (1990-08-01)
After loading of the incubated rat vas deferens with 0.2 mumol/l 3H-noradrenaline (followed by 100 min of wash-out with amine-free solution), the efflux of endogenous and exogenous compounds was determined by HPLC with electrochemical detection and by column chromatography with
D R Bull et al.
Neuroscience letters, 134(1), 41-44 (1991-12-16)
The present study has employed the technique of fast cyclic voltammetry to measure electrically-evoked dopamine release within the central amygdaloid complex in a rat brain slice. Local electrical stimulation caused the release of an electroactive substance which was identified, biochemically
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