P2171
3-Pyridinealdehyde adenine dinucleotide
Synonym(s):
3-Pyridinealdehyde-DPN
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About This Item
Empirical Formula (Hill Notation):
C21H26N6O14P2
CAS Number:
Molecular Weight:
648.41
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
Assay
≥90%
storage temp.
−20°C
SMILES string
Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OCC4OC(C(O)C4O)[N]5=CC(C=O)=CC=C5)C(O)C3O
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Application
3-Pyridinealdehyde adenine dinucleotide is an analogue of NAD that may be used to study the structure and function of NAD binding enzymes such as glyceraldehyde 3-phosphate dehydrogenase, NAD malic enzymes, lactate dehydrogenase and saccharopine dehydrogenase from S. cerevisiae.
Linkage
Analog of NAD
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Hengyu Xu et al.
Biochemistry, 46(25), 7625-7636 (2007-06-05)
A survey of NADH, alpha-Kg, and lysine analogues has been undertaken in an attempt to define the substrate specificity of saccharopine dehydrogenase and to identify functional groups on all substrates and dinucleotides important for substrate binding. A number of NAD
R D LaReau et al.
Biochemistry, 31(17), 4174-4180 (1992-05-05)
Lactate dehydrogenase catalyzes the stereospecific hydride transfer to and from the re face of the nicotinamide coenzyme. The demonstrated probability of transfer to the si face of less than 2 x 10(-8) indicates that the free energy of any diastereotopic
E J Hill et al.
The Journal of biological chemistry, 250(5), 1734-1740 (1975-03-10)
Glyceraldehyde 3-phosphate dehydrogenase (D-glyceraldehyde-3-phoshate:nicotinamide adenine dinucleotide oxidoreductase (phosphorylating), EC 1.2.1.12) forms a complex with 3-pyridinealdehyde-NAD which survives precipitation with 7% perchloric acid. The molar ratio bound 3-pyridinealdehyde-NAD to the enzyme is 2.5 to 2.9. Lactate, malate, and alcohol dehydrogenases do
P M Weiss et al.
Biochemistry, 30(23), 5755-5763 (1991-06-11)
Deuterium isotope effects and 13C isotope effects with deuterium- and protium-labeled malate have been obtained for both NAD- and NADP-malic enzymes by using a variety of alternative dinucleotide substrates. With nicotinamide-containing dinucleotides as the oxidizing substrate, the 13C effect decreases
Sahng Ha Lee et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(18), 5490-5495 (2012-04-11)
NAD analogues can be employed as artificial electron carriers for photoenzymatic synthesis under visible light. Four different NAD analogues that have a 3-substituted pyridine ring have been investigated. 3-Acetylpyridine adenine dinucleotide and 3-pyridinealdehyde adenine dinucleotide were photochemically reduced much more
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