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M4199

Sigma-Aldrich

Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse

lyophilized powder

Synonym(s):

MOG (40-54)

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About This Item

Empirical Formula (Hill Notation):
C84H127N27O21
CAS Number:
Molecular Weight:
1851.08
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

rat

Quality Level

Assay

≥97% (HPLC)

form

lyophilized powder

color

white

solubility

deionized water: soluble

UniProt accession no.

storage temp.

−20°C

Gene Information

mouse ... Mog(17441)
rat ... Mog(24558)

Related Categories

Amino Acid Sequence

Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly

Biochem/physiol Actions

The 21-residue peptide MOG 35-55 contains an antigenic epitope responsible for the activation of CD8 encephalitogenic T cells in mice. Two truncated peptides, MOG 40-54 and MOG 44-54 were shown to bind the recombinant H-2Db protein. This complex then binds MOG specific CD8 T cells. While MOG 40-54 retained the full capability of inducing paralytic disease, MOG 44-54 only partialy causes clinical paralysis and central nervous system inflamation.

Physical form

Lyophilized from 0.1% aqueous TFA.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Novel pathogenic epitopes of myelin oligodendrocyte glycoprotein induce experimental autoimmune encephalomyelitis in C57BL/6 mice
Cecile Delarasse
Immunology (2013)
Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by chronic ethanol consumption.
Okamoto H
Neuroscience Letters (2006)

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