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K1250

Sigma-Aldrich

6-Ketocholestanol

Synonym(s):

3β-Hydroxy-5α-cholestan-6-one, 5α-Cholestan-3β-ol-6-one

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About This Item

Empirical Formula (Hill Notation):
C27H46O2
CAS Number:
1175-06-0
Molecular Weight:
402.65
EC Number:
214-640-5
MDL number:
MFCD00003572
UNSPSC Code:
12352200
PubChem Substance ID:
24896203

form

solid

SMILES string

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC(=O)[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-20-16-25(29)24-15-19(28)11-13-27(24,5)23(20)12-14-26(21,22)4/h17-24,28H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,24-,26-,27-/m1/s1

InChI key

JQMQKOQOLPGBBE-ZNCJEFCDSA-N

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
069H1195
129F0459

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Barbara G Auner et al.
International journal of pharmaceutics, 294(1-2), 149-155 (2005-04-09)
Phloretin and 6-ketocholestanol are penetration enhancers for percutaneous delivery of certain topically applied drugs. In the present study some physicochemical experiments have been performed to elucidate the mechanism of action of phloretin and 6-ketocholestanol. The penetration enhancing effect of phloretin
Josep Cladera et al.
Journal of pharmaceutical sciences, 92(5), 1018-1027 (2003-04-25)
In the present work, we report the possibility of modifying the electrostatic properties of the skin by treating human epidermis with compounds whose structures possess a large molecular dipole moment. Data are presented showing that such a modification can be
Mark F Vitha et al.
Biochimica et biophysica acta, 1768(1), 107-114 (2006-08-15)
We are interested in developing fluorescence methods for quantifying lateral variations in the dipole potential across cell surfaces. Previous work in this laboratory showed that the ratio of fluorescence intensities of the voltage-sensitive dye di-8-ANEPPS using excitation wavelengths at 420
T Asawakarn et al.
The Journal of biological chemistry, 276(42), 38457-38463 (2001-08-14)
The combined use of the membrane surface potential fluorescent sensor fluorescein phosphatidylethanolamine (FPE) and the membrane dipole potential fluorescent sensor di-8-ANEPPS to characterize the interaction of molecules with model and cellular membranes and to asses the influence of the dipole
Xin-Min Li et al.
Biophysical journal, 85(6), 3788-3801 (2003-12-04)
Membrane microdomains, such as caveolae and rafts, are enriched in cholesterol and sphingomyelin, display liquid-ordered phase properties, and putatively function as protein organizing platforms. The goal of this investigation was to identify sterol and sphingomyelin structural features that modulate surface
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