C2363
Monoclonal Anti-phospho-β-Catenin (pSer33) antibody produced in mouse
clone BC-76, purified immunoglobulin, buffered aqueous solution
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About This Item
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biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
BC-76, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
microarray: suitable
western blot: 5 μg/mL using total cell extracts of cultured HEK-293T cells treated with MG132
isotype
IgM
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer33)
Gene Information
human ... CTNNB1(1499)
General description
Cateninβ is a multifunctional protein, coded by CTNNB1 (cateninβ 1) gene. It is present in the intracellular side of the cytoplasmic membrane. It is located on human chromosome 3p22.1.
Immunogen
synthetic phosphopeptide corresponding to the region that contains serine 33 of human β-catenin.
Application
Monoclonal Anti-phospho-β-Catenin (pSer33) antibody produced in mouse is suitable for microarray and western blotting at a concentration of 5μg/mL using total cell extracts of cultured HEK-293T cells treated with MG132.
Biochem/physiol Actions
Catenin (cadherin-associated protein), β 1 (88kDa) protein is encoded by CTNNB1 gene in humans. It is also called as β-catenin. It is a dual function protein that regulates the coordination of cell-cell adhesion and gene transcription. Human β-catenin is located at band p21 on chromosome 3.
Mutations in β-catenin results in retinal vascular condition FEVR (familial exudative vitreoretinopathy). It participates in stimulating disease progression, providing BCR–ABL (fusion gene) kinase-independent resistance and LSC (leukemic stem cell) self-renewal. CTNNB1 plays an important role in cell-to-cell adhesion and transcriptional modulation in the Wnt signalling pathway.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Certificates of Analysis (COA)
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Combined inhibition of β-catenin and Bcr?Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo.
Zhou H, et al.
Leukemia, 31(10), 2065?2074-2065?2074 (2017)
P D McCrea et al.
Science (New York, N.Y.), 254(5036), 1359-1361 (1991-11-29)
Three cytoplasmic proteins, called catenins, bind to the cytoplasmic tail of the epithelial cell-cell adhesion molecule E-cadherin. The complementary DNA sequence was determined for the 92-kilodalton beta catenin of Xenopus laevis. The sequence is homologous to mammalian plakoglobin, a protein
β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation.
Geyer FC, et al.
Modern Pathology, 24(2), 209?231-209?231 (2011)
Defects in the Cell Signaling Mediator ?-Catenin Cause the Retinal Vascular Condition FEVR
Panagiotou ES, et al.
American Journal of Human Genetics, 100(6), 960-968 (2017)
C Kraus et al.
Genomics, 23(1), 272-274 (1994-09-01)
The human beta-catenin locus (CTNNB1) was mapped by in situ fluorescence analysis to band p21 on the short arm of chromosome 3, a region frequently affected by somatic alterations in a variety of tumors. PCR primers for the genomic amplification
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