C1835
(S)-(+)-4-Carboxyphenylglycine
Synonym(s):
(S)-α-Amino-4-carboxyphenylacetic acid, L-α-(4-Carboxyphenyl)glycine, S-4CPG
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About This Item
Empirical Formula (Hill Notation):
C9H9NO4
CAS Number:
Molecular Weight:
195.17
MDL number:
UNSPSC Code:
12352103
solubility
0.1 M NaOH: 15 mg/mL
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Biochem/physiol Actions
Competitive mGluR1 metabotropic glutamate receptor antagonist; mGluR2 metabotropic glutamate receptor agonist.
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S A Eaton et al.
European journal of pharmacology, 244(2), 195-197 (1993-01-15)
Two phenylglycine derivates, (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine, competitively antagonised (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD)-stimulated phosphoinositide hydrolysis in rat cerebral cortical slices. The same phenylglycine derivatives selectively antagonized ACPD-induced depolarization in neonatal rat spinal motoneurones and rate thalamic neurones relative to depolarization or excitation induced
Pharmacological analysis of carboxyphenyl-glycines at metabotropic glutamate receptors.
Cavanni, et al.
Eur. J. Pharmacol., Molec. Pharmacol. Sec., 269, 9-9 (1994)
E F Birse et al.
Neuroscience, 52(3), 481-488 (1993-02-01)
The possible roles of G-protein coupled metabotropic glutamate receptors in central nervous function are currently the focus of intensive investigation. The complexity of effects produced by agonists at these receptors probably reflects the activity of a range of sub-types. The
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