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C0662

Sigma-Aldrich

6-Carboxyfluorescein

~97% purity (HPLC), powder

Synonym(s):

6-FAM, FLUOS

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$288.00

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50 MG
$288.00

About This Item

Empirical Formula (Hill Notation):
C21H12O7
CAS Number:
3301-79-9
Molecular Weight:
376.32
Beilstein:
54341
MDL number:
MFCD00036873
UNSPSC Code:
12171500
PubChem Substance ID:
24892266
NACRES:
NA.47

$288.00

Please contact Customer Service for Availability
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Product Name

6-Carboxyfluorescein, ≥96% (HPLC)

Quality Level

200

Assay

≥96% (HPLC)

form

powder

technique(s)

titration: suitable

color

dark yellow to dark orange

mp

>300 °C (lit.)

solubility

0.1 M NaOH: 9.80-10.20 mg/mL, clear to slightly hazy, orange

λmax

492 nm at 0.1 N in NaOH

fluorescence

λex 492 nm; λem 517 nm (pH 8.0)

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

2-8°C

SMILES string

OC(=O)c1ccc2C(=O)OC3(c4ccc(O)cc4Oc5cc(O)ccc35)c2c1

InChI

1S/C21H12O7/c22-11-2-5-14-17(8-11)27-18-9-12(23)3-6-15(18)21(14)16-7-10(19(24)25)1-4-13(16)20(26)28-21/h1-9,22-23H,(H,24,25)

InChI key

BZTDTCNHAFUJOG-UHFFFAOYSA-N

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Application

6-Carboxyfluorescein has been used to check the plasma membrane integrity in sperm cells.[1]
Fluorescent dye.

Biochem/physiol Actions

6-Carboxyfluorescein diacetate is a membrane permeable compound. It can be hydrolysed by intracellular esterases to form a membrane impermeable bright green fluorescent molecule, 6-carboxyfluorescein.[2]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000338459
0000338459
0000258268
0000239442
0000258268

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Bikash Malla et al.
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Monitoring of environmental water is crucial to protecting humans and animals from possible health risks. Although numerous human-specific viral markers have been designed to track the presence of human fecal contamination in water, they lack adequate sensitivity and specificity in
Przemysław Płociński et al.
Nature communications, 8(1), 1251-1251 (2017-11-02)
Prokaryotic Ligase D is a conserved DNA repair apparatus processing DNA double-strand breaks in stationary phase. An orthologous Ligase C (LigC) complex also co-exists in many bacterial species but its function is unknown. Here we show that the LigC complex
Andrew B Janowski et al.
mBio, 10(4) (2019-07-11)
Recent advances in unbiased pathogen discovery have implicated astroviruses as pathogens of the central nervous system (CNS) of mammals, including humans. However, the capacity of astroviruses to be cultured in CNS-derived cells in vitro has not been reported to date.
Harshad Ingle et al.
Nature microbiology, 4(7), 1120-1128 (2019-04-03)
Commensal microbes profoundly impact host immunity to enteric viral infections1. We have shown that the bacterial microbiota and host antiviral cytokine interferon-λ (IFN-λ) determine the persistence of murine norovirus in the gut2,3. However, the effects of the virome in modulating
Kako Ohbayashi et al.
Scientific reports, 7(1), 10933-10933 (2017-09-09)
The magnitude and frequency of disturbances affect species diversity and spatial distributions, but the direct effects of large-scale disturbances on genetic diversity are poorly understood. On March 11, 2011, the Great Tohoku Earthquake in Japan caused a massive tsunami that
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