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B0383

Sigma-Aldrich

Benzil

Synonym(s):

Dibenzoyl, Diphenylethanedione

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About This Item

Linear Formula:
C6H5COCOC6H5
CAS Number:
134-81-6
Molecular Weight:
210.23
Beilstein:
608047
EC Number:
205-157-0
MDL number:
MFCD00003080
UNSPSC Code:
12352100
PubChem Substance ID:
24891516

vapor pressure

1 mmHg ( 128.4 °C)

mp

94-95 °C (lit.)

SMILES string

O=C(c1ccccc1)C(=O)c2ccccc2

InChI

1S/C14H10O2/c15-13(11-7-3-1-4-8-11)14(16)12-9-5-2-6-10-12/h1-10H

InChI key

WURBFLDFSFBTLW-UHFFFAOYSA-N

Gene Information

human ... ACHE(43) , BCHE(590) , CES1(1066)

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

356.0 °F - closed cup

Flash Point(C)

180 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Craig E Wheelock et al.
Bioorganic & medicinal chemistry, 16(4), 2114-2130 (2007-11-21)
Carboxylesterases metabolize numerous exogenous and endogenous ester-containing compounds including the chemotherapeutic agent CPT-11, anti-influenza viral agent oseltamivir, and many agrochemicals. Trifluoromethyl ketone (TFK)-containing compounds with a sulfur atom beta to the ketone moiety are some of the most potent carboxylesterase
Elizabeth I Parkinson et al.
Bioorganic & medicinal chemistry, 19(15), 4635-4643 (2011-07-08)
Carboxylesterases (CE) are ubiquitous enzymes found in both human and animal tissues and are responsible for the metabolism of xenobiotics. This includes numerous natural products, as well as a many clinically used drugs. Hence, the activity of these agents is
Latorya D Hicks et al.
Bioorganic & medicinal chemistry, 15(11), 3801-3817 (2007-04-03)
We have synthesized and assessed the ability of symmetrical fluorobenzoins and fluorobenzils to inhibit mammalian carboxylesterases (CE). The majority of the latter were excellent inhibitors of CEs however unexpectedly, the fluorobenzoins were very good enzyme inhibitors. Positive correlations were seen
Janice L Hyatt et al.
Journal of medicinal chemistry, 48(17), 5543-5550 (2005-08-19)
Benzil has been identified as a potent selective inhibitor of carboxylesterases (CEs). Essential components of the molecule required for inhibitory activity include the dione moiety and the benzene rings, and substitution within the rings affords increased selectivity toward CEs from
Toshiyuki Harada et al.
Bioorganic & medicinal chemistry, 17(1), 149-164 (2008-12-09)
Carboxylesterases are enzymes that hydrolyze a broad suite of endogenous and exogenous ester-containing compounds to the corresponding alcohol and carboxylic acid. These enzymes metabolize a number of therapeutics including the anti-tumor agent CPT-11, the anti-viral drug oseltamivir, and the anti-thrombogenic
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