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Key Documents

AV48994

Sigma-Aldrich

Anti-CHST14 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

35 kDa

species reactivity

human, dog, rat, mouse, pig, bovine

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_569735

UniProt accession no.

Q8NCH0

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CHST14(113189)

Immunogen

Synthetic peptide directed towards the middle region of human CHST14

Application

Anti-CHST14 antibody produced in rabbit is suitable for western blotting at a concentration of 1.0μg/ml.

Biochem/physiol Actions

Carbohydrate (N-acetylgalactosamine 4-0-sulfotransferase 14, CHST14; D4ST1) catalyzes the transfer of sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate.CHST14 regulates the proliferation and neurogenesis process in neural progenitor cells.[1] Mutations in CHST14 gene causes adducted thumb-clubfoot syndrome.[2]

Sequence

Synthetic peptide located within the following region: REYQQRYGAEIVRRYRAGAGPSPAGDDVTFPEFLRYLVDEDPERMNEHWM

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC19837

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Munis Dündar et al.
American journal of human genetics, 85(6), 873-882 (2009-12-17)
Adducted thumb-clubfoot syndrome is an autosomal-recessive disorder characterized by typical facial appearance, wasted build, thin and translucent skin, congenital contractures of thumbs and feet, joint instability, facial clefting, and coagulopathy, as well as heart, kidney, or intestinal defects. We elucidated
Shan Bian et al.
Journal of cell science, 124(Pt 23), 4051-4063 (2011-12-14)
Chondroitin sulfates (CSs) and dermatan sulfates (DSs) are enriched in the microenvironment of neural stem cells (NSCs) during development and in the adult neurogenic niche, and have been implicated in mechanisms governing neural precursor migration, proliferation and differentiation. In contrast

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