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65325

Sigma-Aldrich

8-Methoxypyrene-1,3,6-trisulfonic acid trisodium salt

for fluorescence, ≥98.0% (TLC)

Synonym(s):

PTS1, Trisodium 8-methoxypyrene-1,3,6-trisulfonate

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About This Item

Empirical Formula (Hill Notation):
C17H9Na3O10S3
CAS Number:
82962-86-5
Molecular Weight:
538.41
MDL number:
MFCD07437980
UNSPSC Code:
12352200
PubChem Substance ID:
329760049
NACRES:
NA.32

grade

for fluorescence

Quality Level

100

Assay

≥98.0% (TLC)

form

solid

mp

253-260 °C (dec.) (lit.)

solubility

DMF: soluble
DMSO: soluble
H2O: soluble
methanol: soluble

fluorescence

λex 404 nm; λem 431 nm in H2O

SMILES string

[Na+].[Na+].[Na+].COc1cc(c2ccc3c(cc(c4ccc1c2c34)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O

InChI

1S/C17H12O10S3.3Na/c1-27-12-6-13(28(18,19)20)9-4-5-11-15(30(24,25)26)7-14(29(21,22)23)10-3-2-8(12)16(9)17(10)11;;;/h2-7H,1H3,(H,18,19,20)(H,21,22,23)(H,24,25,26);;;/q;3*+1/p-3

InChI key

GUGNSJAORJLKGP-UHFFFAOYSA-K

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Application

8-Methoxypyrene-1,3,6-trisulfonic acid may be used as a fluorescent marker for studies of aerosolized drug delivery vehicles and as a highly water soluble superpolar fluorescent probe for assaying cationic surfactants

Other Notes

Highly water soluble superpolar fluorescent probe for assaying cationic surfactants

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCB7800

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Kerstin Lahnstein et al.
International journal of pharmaceutics, 351(1-2), 158-164 (2007-11-06)
For the development of aerosolized controlled release formulations such as liposomes or nanoparticles, the use of suitable model drugs is necessary. This study compared the pulmonary absorption of the three structurally diverse fluorescent markers 5(6)-carboxyfluorescein (CF), 8-methoxypyrene-1,3,6-trisulfonic acid trisodium salt
Moritz Beck-Broichsitter et al.
International journal of pharmaceutics, 367(1-2), 169-178 (2008-10-14)
The use of colloidal carrier systems for pulmonary drug delivery is an emerging field of interest in nanomedicine. The objective of this study was to compare the pulmonary absorption and distribution characteristics of the hydrophilic model drug 5(6)-carboxyfluorescein (CF) after
Rania Salama et al.
Current drug delivery, 6(4), 404-414 (2009-06-19)
Delivering therapeutic agents to the airways maximizes their concentration in lung tissue, decreasing systemic exposure or facilitating systemic absorption as desired. Many formulations exist for the treatment of respiratory illnesses however, no controlled release inhalation formulation exists to-date. This review
S. Marhold et al.
Fresenius Journal of Analytical Chemistry, 336, 111-111 (1990)

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