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292664

Sigma-Aldrich

N-tert-Butyl-α-(2-sulfophenyl)nitrone sodium salt

95%

Synonym(s):

2-SPBN sodium salt, 2-Sulfonatophenyl tert-butyl nitrone sodium salt

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About This Item

Linear Formula:
NaO3SC6H4CH=N(O)C(CH3)3
CAS Number:
73475-11-3
Molecular Weight:
279.29
MDL number:
MFCD00012017
UNSPSC Code:
12171500
PubChem Substance ID:
24857605
NACRES:
NA.47

Assay

95%

form

powder or crystals

mp

246 °C (dec.) (lit.)

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Na+].CC(C)(C)[N+](\[O-])=C\c1ccccc1S([O-])(=O)=O

InChI

1S/C11H15NO4S.Na/c1-11(2,3)12(13)8-9-6-4-5-7-10(9)17(14,15)16;/h4-8H,1-3H3,(H,14,15,16);/q;+1/p-1/b12-8-;

InChI key

LAIQBHGUFDAJKL-JCTPKUEWSA-M

Application

Water-soluble, negatively-charged spin trap used to monitor aqueous phase of SDS micelles.[1]

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
10807DJ
13502HU
06816TF
21323LD
15211CZ

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O A Andreassen et al.
Neuroreport, 12(15), 3371-3373 (2001-11-17)
There is substantial evidence implicating excitotoxicity and oxidative damage in the pathogenesis of Huntington's disease (HD). We therefore examined whether the antioxidants 2-sulpho-tert-phenyibutyinitrone (S-PBN) and alpha-lipoic acid could exert neuroprotective effects in transgenic mouse models of HD. S-PBN showed no
N Marklund et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 21(11), 1259-1267 (2001-11-10)
In previous studies, the authors showed that the nitrone radical scavenger alpha-phenyl-N- tert -butyl nitrone (PBN) and its sulfo-derivative, 2-sulfo-phenyl-N- tert -butyl nitrone (S-PBN), attenuated cognitive disturbance and reduced tissue damage after traumatic brain injury (TBI) in rats. In the
S Isenmann et al.
The European journal of neuroscience, 10(8), 2751-2756 (1998-10-10)
Following intraorbital transection of the optic nerve (ON) in rats, more than 80% of the retinal ganglion cell (RGC) population die by apoptosis within 14 days. Repeated intraocular injection of brain-derived neurotrophic factor (BDNF) has been efficient in enhancing RGC
Donald L Ewert et al.
Hearing research, 285(1-2), 29-39 (2012-02-14)
Exposure to blast overpressure has become one of the hazards of both military and civilian life in many parts of the world due to war and terrorist activity. Auditory damage is one of the primary sequela of blast trauma, affecting
Fredrik Clausen et al.
Journal of neurotrauma, 24(8), 1295-1307 (2007-08-23)
Infiltration of T lymphocytes is a key feature in transplant rejection and in several autoimmune disorders, but the role of T lymphocytes in traumatic brain injury (TBI) is largely unknown. Here we studied trafficking of immune cells in the brain
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