06725
N-(2-Aminoethyl)-5-isoquinolinesulfonamide hydrochloride
≥97.0% (HPLC)
Synonym(s):
H-9
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About This Item
Empirical Formula (Hill Notation):
C11H13N3O2S · HCl
CAS Number:
Molecular Weight:
287.77
Beilstein:
6548866
MDL number:
UNSPSC Code:
12352202
Assay
≥97.0% (HPLC)
solubility
methanol: 1 mg/mL, clear, colorless
SMILES string
Cl.NCCNS(=O)(=O)c1cccc2cnccc12
Biochem/physiol Actions
Selective casein kinase 1 inhibitor. Potent inhibitor of histamine release from human basophils when induced by phorbol ester or DiC8, but not when induced by anti-IgE, fMLP (formyl-Met-Leu-Phe) and calcium ionophore A23187. This implicates divergent pathways of basophil activation.
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D O Thueson et al.
Biochemical and biophysical research communications, 144(2), 732-740 (1987-04-29)
The release of histamine and other inflammatory mediators from human basophils is triggered by numerous stimuli, including chemical, physical and receptor-mediated activators. Several mechanisms of cell activation including protein kinase C activation have been proposed to operate in these cells.
T Chijiwa et al.
The Journal of biological chemistry, 264(9), 4924-4927 (1989-03-25)
When screening various isoquinolinesulfonamide compounds which we synthesized, CKI-7, N-(2-amino-ethyl)-5-chloroisoquinoline-8-sulfonamide, was found to have a potent inhibitory action against casein kinase I and a much weaker effect on casein kinase II and other protein kinases. Kinetic analysis indicated that CKI-7
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