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MAB1155

Sigma-Aldrich

Anti-Interferon-α/β Receptor Chain 2 Antibody, clone MMHAR-2

clone MMHAR-2, Chemicon®, from mouse

Synonym(s):

CD118

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MMHAR-2, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

isotype

IgG2a

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... IFNA1(3439)

Related Categories

Specificity

Reacts with Human Interferon alpha/beta Receptor Chain 2 (CD118). Antibody neutralizes human interferon alpha receptor, interacts with extracellular domain, binds to human interferon alpha receptor with high affinity, and blocks biological action of Type I interferons.

Immunogen

Human Interferon alpha/beta Receptor Chain 2

Application

Anti-Interferon-α/β Receptor Chain 2 Antibody, clone MMHAR-2 is an antibody against Interferon-α/β Receptor Chain 2 for use in FC, IP, IH.
Biological Studies

Immunoprecipitation: (1-5 μg/mL)

Immunohistochemistry: (1μg/mL)

Flow cytometry: (1 μg/10 mL - block cells with 50% human AB serum)

Optimal working dilutions must be determined by end user.
Research Category
Inflammation & Immunology
Research Sub Category
Cytokines & Cytokine Receptors

Physical form

Format: Purified
Purified immunoglobulin. Liquid in PBS containing 0.1% bovine serum albumin (BSA).

Storage and Stability

Maintain frozen at -20°C or below for retention of full activity, for up to 12 months. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ting Zhang et al.
Hepatology (Baltimore, Md.), 42(4), 819-827 (2005-09-22)
The chronicity of hepatitis C virus (HCV) infection raises the question of how HCV is able to persist in hepatic cells. We show that human primary hepatocytes and human hepatic cell lines (Huh7 and HepG2) spontaneously produce interferon (IFN)-alpha that
Aura Muntasell et al.
Frontiers in immunology, 4, 40-40 (2013-02-27)
Natural killer (NK) cells play an important role in the defense against viral infections. Activation of resting NK cells is tightly controlled by the balance of surface inhibitory and activating receptors and aided by cytokines released by accessory cells along
Chlamydia trachomatis-infected epithelial cells and fibroblasts retain the ability to express surface-presented major histocompatibility complex class I molecules.
Kagebein, D; Gutjahr, M; Gro?e, C; Vogel, AB; Rodel, J; Knittler, MR
Infection and Immunity null
Hye Joung Choi et al.
Breast cancer research : BCR, 17, 6-6 (2015-01-16)
Estrogen deprivation using aromatase inhibitors (AIs) is currently the standard of care for postmenopausal women with hormone receptor-positive breast cancer. Unfortunately, the majority of patients treated with AIs eventually develop resistance, inevitably resulting in patient relapse and, ultimately, death. The
Hera Kim et al.
PloS one, 16(10), e0258989-e0258989 (2021-10-28)
Toll-like receptors (TLRs) are highly-conserved pattern recognition receptors that mediate innate immune responses to invading pathogens and endogenous danger signals released from damaged and dying cells. Activation of TLRs trigger downstream signaling cascades, that culminate in the activation of interferon

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