BATF3, also known as Basic leucine zipper transcriptional factor ATF-like 3, B-ATF-3, 21 kDa small nuclear factor isolated from T-cells, or Jun dimerization protein p21SNFT, and encoded by the gene BATF3/SNFT, is an AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. BATF3 is required for the development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8. BATF3 acts via the formation of a heterodimer with JUN family proteins that recognizes and bind the DNA sequence 5′-TGA[CG]TCA-3′ and thus regulates the expression of the target genes. BATF3 is localized to the nucleus. BATF3 is expressed in myeloid dendritic cells and T cell precursor immune cells primarily.
Immunogen
Epitope: Leucine-zipper
KLH-conjugated linear peptide corresponding to the Leucine-zipper of human BATF3.
Application
Detect BATF3 using this Anti-BATF3 antibody validated for use in western blotting & flow cytometry.
Flow Cytometry Analysis: 1 µg of this antibody detected BATF3 in human PBMC cells.
Research Category Epigenetics & Nuclear Function
Research Sub Category Nuclear Receptors
Quality
Evaluated by Western Blotting in human spleen tissue lysate.
Western Blotting Analysis: 0.25 µg/mL of this antibody detected BATF3 in 10 µg of human spleen tissue lysate.
Target description
~17 kDa observed
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Basic leucine zipper transcription factor ATF-like (BATF) -3 is a member of the activator protein 1 (AP‑1) family of transcription factors and is known to play a vital role in regulating differentiation of antigen-presenting cells in mammals. In this study
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