5.06125

Paroxetine Hydrochloride

• Synonym(s): Paroxetine Hydrochloride, 5-HT transporter, Paroxetine, Paxil
• Empirical Formula (Hill Notation): C₁₉H₂₀FNO₃ · xHCl
• CAS Number: 110429-35-1
• Molecular Weight: 329.37 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥99% (HPLC)
• Quality Level: 100
• form: solid
• potency: 0.065 nM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: soluble
• storage temp.: 2-8°C
• InChI: 1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1
• InChI key: AHOUBRCZNHFOSL-YOEHRIQHSA-N

Description

General description

A very potent uptake inhibitor highly selective for 5-HT transporter (K_i = 0.065 nM and 0.05 nM for human and rat 5-HT transporters, respectively). A popular antidepressant drug of the SSRI type. Used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, posttraumatic stress disorder, generalized anxiety disorder and vasomotor symptoms.

Biochem/physiol Actions

Primary Target
5-HT Uptake Transporter

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Brittain, G., et al. 2012. Profiles of drug substances, excipients, and related methodology.38, 407.
Bourin, M., et al. 2001. CNS Drug Rev.7, 25.
Thomas, R., et al. 1997. Psychopharmacology (Berl).93, 193.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H302 - H317 - H319 - H411
• Precautionary Statements: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable