1951-M

Bacitracin

• Synonym(s): Bacitracin, Altracin, PDI Inhibitor I, Protein Disulfide Isomerase Inhibitor I
• CAS Number: 1405-87-4
• MDL number: MFCD00062640
• UNSPSC Code: 12352200

Properties

• form: solid
• Quality Level: 100
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: gray-white
• solubility: ethanol: soluble; water: soluble
• storage temp.: 2-8°C
• InChI: 1S/C66H103N17O16S.Zn/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90;/h12-14,18-19,31,33-37,39-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88);
• InChI key: QSNOBVJFKSQBBD-UHFFFAOYSA-N

Description

General description

A polypeptide antibiotic and a peptidase inhibitor. Active against gram-positive microorganisms. An inhibitor of protein disulfide isomerase. Resembles penicillin in causing protoplast formation and inhibition of cell wall synthesis. Blocks the regeneration of the carrier phospholipid. Stimulates 5-hydroxytryptamine receptors and increases vascular resistance. Bacitracin is unstable in alkaline solutions. Note: Do not use a glass rod for stirring the solution, it may cause some precipitation.

A polypeptide antibiotic and peptidase inhibitor. An inhibitor of protein disulfide isomerase. Resembles penicillin in causing protoplast formation and inhibition of cell wall synthesis. Blocks the regeneration of carrier phospholipid. Stimulates 5-hydroxytryptamine receptors and increases vascular resistance.

Note: 1 KU = 1000 units.

Biochem/physiol Actions

Potency ≥40 Bacitracin units/mg solid, as is

Warning

Toxicity: Standard Handling (A)

Unit Definition

One unit is defined as the amount of antibiotic equal to 26 µg of the USP standard. Note: 1 ku = 1000 units.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Ikai, Y., et al. 1995. J. Antibiot. (Tokyo) 48, 233.
Clive, D.R., et al. 1994. Exp. Cell Res. 214, 139.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable