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857132C

Avanti

14:0 Hemi BMP (S,R)

sn-(3-myristoyl-2-hydroxy)-glycerol-1-phospho-sn-3′-(1′,2′-dimyristoyl)-glycerol (ammonium salt), chloroform

Synonym(s):

110731

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About This Item

Empirical Formula (Hill Notation):
C48H96NO11P
CAS Number:
325466-04-4
Molecular Weight:
894.25
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (857132C-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 857132C

concentration

5 mg/mL (857132C-5mg)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP(OC[C@@]([H])(O)COC(CCCCCCCCCCCCC)=O)([O-])=O)(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O.[NH4+]

General description

Bis(monoacylglycerol) phosphate (BMP) is a phospholipid, containing two-phosphate linked fatty acid esterified glycerol molecule. It is present in late endosome, majorly in intraluminal vesicles (ILVs) and is hydrolyzed by BMP hydrolase.[1] BMP accounts to 15% of total organelle lipids.[2]

Application

14:0 Hemi BMP (S,R) is suitable to use as ISTDs (internal standards) for the extraction of phospholipids.[3]

Biochem/physiol Actions

Bis(monoacylglycerol)phosphate (BMP) plays a key role in cargo sorting[1] and protein and lipid trafficking.[2] The levels of BMP is elevated in lysosomal storage disorders (LSD) including Wolman disease, Niemann Pick disease and neuronal ceroid lipofuscinoses. It is resistant to degradation by the enzyme, acid phospholipase.[1]

Packaging

5 mL Clear Glass Sealed Ampule (857132C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

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Effect of lysosomal storage on bis (monoacylglycero) phosphate
Meikle PJ, et al.
The Biochemical Journal, 411(1), 71- 78 (2008)
Metabolic disease and ABHD6 alter the circulating bis (monoacylglycerol) phosphate profile in mice and humans
Grabner GF, et al.
Journal of Lipid Research, jlr-M093351 (2019)
Hirotami Matsuo et al.
Science (New York, N.Y.), 303(5657), 531-534 (2004-01-24)
What are the components that control the assembly of subcellular organelles in eukaryotic cells? Although membranes can clearly be distorted by cytosolic factors, very little is known about the intrinsic mechanisms that control the biogenesis, shape, and organization of organellar

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