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Sigma-Aldrich

Poly(ethylene glycol) linear dendron

carboxyl terminated, PEG Mn 10,000, generation 2

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About This Item

Empirical Formula (Hill Notation):
C486H952O249
Molecular Weight:
10780.61
UNSPSC Code:
51171641
NACRES:
NA.25

form

solid

mol wt

PEG Mn 10,000
generation 2

no. Surface Groups

4

color

white to off-white

storage temp.

−20°C

Related Categories

General description

  • Polymer architecture: PEG-linear dendron
  • Generation: 2
  • PEG average Mn: 10,000
  • End Group Functionality: Carboxylic acid
  • No. Surface Groups: 4
  • Calculated Mol. Wt.: 10780.71 g/mol
  • Bis-MPA = 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolyzable linker allows for degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. This dendritic polymer is biocompatible, biodegradable, and suitable for biomedical applications. PEG-core dendrons feature excellent solubility in water and a high degree of functionality per PEG chain, enabling use in advanced drug delivery systems or for drug targeting. The carboxylic acid-functionalized corona can be readily used for bioconjugation reactions.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications.
Garcia-Gallego S, et al.
Progress in Polymer Science, 48, 85-110 (2015)
Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications.
Garcia-Gallego S, et al
Progress in Polymer Science, 48, 85-110 (2015)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

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Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

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Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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