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About This Item
Empirical Formula (Hill Notation):
C4H2F2N2
CAS Number:
Molecular Weight:
116.07
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Assay
97%
refractive index
n20/D 1.432
bp
118-120 °C
density
1.359 g/mL at 25 °C
SMILES string
Fc1ccnc(F)n1
InChI
1S/C4H2F2N2/c5-3-1-2-7-4(6)8-3/h1-2H
InChI key
JZSYSXZDIQUOGP-UHFFFAOYSA-N
Application
2,4-Difluoropyrimidine can be used as a starting material to synthesize:
- 3-Pyrimidin-4-yl-oxazolidin-2-one derivatives as mutant isocitrate dehydrogenase (IDH1) inhibitors.
- N,N′-(1,4-phenylenebis(methylene))bis(2-fluoropyrimidin-4-amine) as chemokine receptor type 4 antagonists.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
106.0 °F - closed cup
Flash Point(C)
41.1 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Optimization of 3-pyrimidin-4-yl-oxazolidin-2-ones as orally bioavailable and brain penetrant mutant IDH1 inhibitors
Zhao Q, et al.
ACS Medicinal Chemistry Letters, 9(7), 746-751 (2018)
Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity
Zhu A, et al.
Journal of Medicinal Chemistry, 53(24), 8556-8568 (2010)
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