247685

2-Fluoro-6-nitrotoluene

98%

• Linear Formula: CH₃C₆H₃(NO₂)F
• CAS Number: 769-10-8
• Molecular Weight: 155.13
• EC Number: 212-203-3
• MDL number: MFCD00007197
• UNSPSC Code: 12352100
• PubChem Substance ID: 24854883
• NACRES: NA.22

Properties

• Assay: 98%
• form: liquid
• refractive index: n20/D 1.523 (lit.)
• bp: 97 °C/11 mmHg (lit.)
• mp: 6.5-7 °C (lit.)
• density: 1.27 g/mL at 25 °C (lit.)
• SMILES string: Cc1c(F)cccc1[N+]([O-])=O
• InChI: 1S/C7H6FNO2/c1-5-6(8)3-2-4-7(5)9(10)11/h2-4H,1H3
• InChI key: GXPIVRKDWZKIKZ-UHFFFAOYSA-N

Description

General description

2-Fluoro-6-nitrotoluene undergoes reduction in the presence of stannous chloride, followed by benzoylation to yield N-(3-fluoro-o-tolyl)benzamide. 2-Fluoro-6-nitrotoluene undergoes reaction with concentrated nitric acid at 100°C to yield 2-fluoro-6-nitrobenzoic acid.

Application

2-Fluoro-6-nitrotoluene has been used in the preparation of 4-fluoroindole via Leimgruber-Batcho procedure.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 + H312 + H332,H315,H319,H335
• Precautionary Statements: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): 192.2 °F - closed cup
• Flash Point(C): 89 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves