V5390

VU0029251

≥98% (HPLC), powder

• Synonym(s): 6,7-Dihydro-2-(methylthio)-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine
• Empirical Formula (Hill Notation): C₁₀H₁₁N₃S₂
• Molecular Weight: 237.34
• MDL number: MFCD00698485
• UNSPSC Code: 12352200
• PubChem Substance ID: 329829058
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥11 mg/mL
• storage temp.: 2-8°C
• SMILES string: CSc1nc(N)c2c3CCCc3sc2n1
• InChI: 1S/C10H11N3S2/c1-14-10-12-8(11)7-5-3-2-4-6(5)15-9(7)13-10/h2-4H2,1H3,(H2,11,12,13)
• InChI key: WDDBZCKBRCTSOZ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

VU0029251 is the first example of a partial mGluR5 partial antagonist that is not based on the MPEP scaffold. The compound displays a maximum inhibition of 50% activity, and cannot completely displace [3H] MPEP, suggesting that competition for MPEP is also allosteric, involving a unique site.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable