V2514
Anti-VGLUT2 (HY-19) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-DNPI, Anti-VGLUT2
Sign Into View Organizational & Contract Pricing
Select a Size
200 μL
7 230,00 kr
7 230,00 kr
Please contact Customer Service for Availability
A recombinant, preservative-free antibody is available for your target. Try ZMS1026
Request a Bulk Order
All Photos(2)
Select a Size
Change View
200 μL
7 230,00 kr
About This Item
7 230,00 kr
Please contact Customer Service for Availability
A recombinant, preservative-free antibody is available for your target. Try ZMS1026
Request a Bulk Order
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 65 kDa
species reactivity
rat
technique(s)
western blot: 1:2,000 using synaptic vesicle (SV) fraction of rat brain
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLC17A6(57084)
mouse ... Slc17a6(140919)
rat ... Slc17a6(84487)
General description
Vesicular glutamate transporter 2 (vGluT2), also known as solute carrier family 17 member 6 (SLC17A6), is encoded by the gene mapped to human chromosome 11p14.3. The encoded protein belongs to the SLC17 family of transporters. vGluT2 is an integral membrane protein with 12 predicted transmembrane domains. It is localized on synaptic vesicles and is expressed mainly in neurons and endocrine terminals.
Immunogen
synthetic peptide located near the C-terminus of rat VGLUT2 (amino acids 520-538). The sequence is identical in mouse and human VGLUT2 and has no homology to VGLUT1.
Application
Anti-VGLUT2 (HY-19) antibody produced in rabbit has been used in:
- western blot
- immunolabelling.
- immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunofluorescence (1 paper)
Biochem/physiol Actions
Vesicular glutamate transporters (vGluT) play a vital role in the transport of glutamate into secretory vesicles. They are also used as a specific markers to recognize glutamatergic neurons. vGluT2 is considered to be a potent target for reducing glutamatergic neurotransmission. Thus, vGluT2 could be useful for the treatment of neurodegenerative diseases in which chronic excessive glutamate signaling has been involved. It is also used for treating epilepsy and pain.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
recommended
Product No.
Description
Pricing
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Growth and refinement of excitatory synapses in the human auditory cortex.
.Pundir A S, et al.
Brain Structure &Amp; Function, 221(7), 3641-3674 (2016)
Expression of vesicular glutamate transporter 2 (vGluT2) on large dense-core vesicles within GnRH neuroterminals of aging female rats.
Yin W, et al.
PLoS ONE, 10(6), e0129633-e0129633 (2015)
Yun-Ping Deng et al.
Frontiers in systems neuroscience, 8, 198-198 (2014-11-02)
Motor slowing and forebrain white matter loss have been reported in premanifest Huntington's disease (HD) prior to substantial striatal neuron loss. These findings raise the possibility that early motor defects in HD may be related to loss of excitatory input
Confocal laser scanning microscopy and ultrastructural study of VGLUT2 thalamic input to striatal projection neurons in rats.
Lei W, et al.
The Journal of Comparative Neurology, 521(6), 1354-1377 (2013)
Effect of early embryonic deletion of huntingtin from pyramidal neurons on the development and long-term survival of neurons in cerebral cortex and striatum.
Dragatsis I, et al.
Neurobiology of Disease, 111, 102-117 (2017)
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
