SML2723

NVS-ZP7-4

≥98% (HPLC)

• Synonym(s): (S)-1-(2-((6-fluorobenzo[d]thiazol-2-yl)amino)-3-phenylpropyl)-1′H-spiro[piperidine-4,4′-quinazolin]-2′(3′H)-one, 1-[(2S)-2-[(6-fluoro-2-benzothiazolyl)amino]-3-phenylpropyl]-spiro[piperidine-4,4′(1′H)-quinazolin]-2′(3′H)-one
• Empirical Formula (Hill Notation): C₂₈H₂₈FN₅OS
• CAS Number: 2349367-89-9
• Molecular Weight: 501.62
• MDL number: MFCD31813751
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Fc1cc2[s]c(nc2cc1)N[C@H](CN4CCC5(NC(=O)Nc6c5cccc6)CC4)Cc3ccccc3
• InChI: 1S/C28H28FN5OS/c29-20-10-11-24-25(17-20)36-27(32-24)30-21(16-19-6-2-1-3-7-19)18-34-14-12-28(13-15-34)22-8-4-5-9-23(22)31-26(35)33-28/h1-11,17,21H,12-16,18H2,(H,30,32)(H2,31,33,35)/t21-/m0/s1
• InChI key: FZOFDZMKSAUTHT-NRFANRHFSA-N

Description

Biochem/physiol Actions

NVS-ZP7-4 is a potent inhibitor of the Notch signaling pathway that induces endoplasmic reticulum (ER) stress and induces apoptosis in T-ALL cell lines. NVS-ZP7-4 is a potent and selective inhibitor of SLC39A7 (ZIP7) zinc transporter that increases ER zinc levels.

potent inhibitor of the Notch signaling pathway that induces endoplasmic reticulum (ER) stress and induces apoptosis in T-ALL cell lines

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable