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SML2184

Sigma-Aldrich

Kevetrin hydrochloride

≥98% (HPLC)

Synonym(s):

Kevetrin hydrochloride, 4-Isothioureidobutyronitrile hydrochloride, Carbamimidothioic acid 3-cyanopropyl ester hydrochloride, NSC 525990 HCl

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5 MG
927,00 kr
25 MG
2 990,00 kr

927,00 kr

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5 MG
927,00 kr
25 MG
2 990,00 kr

About This Item

Empirical Formula (Hill Notation):
C5H9N3S · HCl
CAS Number:
66592-89-0
Molecular Weight:
179.67
MDL number:
MFCD22572767
UNSPSC Code:
12352200
NACRES:
NA.77

927,00 kr

Please contact Customer Service for Availability
Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

NC(SCCCC#N)=N.Cl

InChI

1S/C5H9N3S.ClH/c6-3-1-2-4-9-5(7)8;/h1-2,4H2,(H3,7,8);1H

InChI key

NCXJZJFDQMKRKM-UHFFFAOYSA-N

Biochem/physiol Actions

Kevetrin is an activator/stabilizer of wild type p53 tumor suppressor protein in human lung carcinoma and ovarian cancer cells that induces cell cycle arrest and apoptosis. Additionally Kevetrin down-regulates oncogenic mutant p53 in OVCAR-3 ovarian cancer cells. Kevetrin inhibits tumor growth in xenograft model of ovarian cancer.
wild type p53 stabilizer

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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