PZ0354

PF-04363467 hydrochloride

≥98% (HPLC)

• Synonym(s): (S)-N-[4-(4-Ethyl-2-morpholinyl)-2-methylphenyl]-4-(1-methylethyl)benzenesulfonamide hydrochloride, N-[4-[(2S)-4-Ethyl-2-morpholinyl]-2-methylphenyl]-4-(1-methylethyl)-benzenesulfonamide hydrochloride, PF-4363467 hydrochloride
• Empirical Formula (Hill Notation): C₂₂H₃₀N₂O₃S · HCl
• CAS Number: 2040055-81-8
• Molecular Weight: 439.01
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 3 mg/mL, clear (warmed)
• storage temp.: room temp
• SMILES string: [H]Cl.CC1=CC([C@H]2CN(CC)CCO2)=CC=C1NS(C3=CC=C(C(C)C)C=C3)(=O)=O

Description

Biochem/physiol Actions

PF-4363467 hydrochloride is a Dopamine D3/D2 receptor antagonist. PF-4363467 has 100-fold selectivity for D3 with a Ki value of 3.1 nM for D3R compared to a Ki value of 692 nM for D2R and high selectivity for D3R compared to other biogenic amine receptors. PF-4363467 attenuated opioid drug-seeking behavior in a rat model of addiction without causing the extrapyramidal symptoms often associated with D2R antagonism.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable