p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.
Immunogen
GST fusion protein of human p53 corresponding to amino acids 1-393.
Application
Monoclonal Anti-p53-Biotin antibody produced in mouse has been used for Western Blotting.
Biochem/physiol Actions
Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.
Physical form
Solution in 0.01 M phosphate buffered saline, containing 0.08% sodium azide.
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Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
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